Contextual Modulation of Visuomotor Signals in the Mouse Cortex

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SPEED-DISSERTATION-2023.pdf (5.99 MB)
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Speed, Anderson
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Wallace H. Coulter Department of Biomedical Engineering
The joint Georgia Tech and Emory department was established in 1997
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https://hdl.handle.net/1853/71952
Abstract
Sensorimotor transformations are a hallmark of natural behaviors. Organisms must modulate their responses to stimuli in their environment based on contextual cues. The mechanisms by which sensory information is taken in, processed, and transformed into a motor action are not well understood. In this thesis, we explore first the relationship between spontaneous fluctuations in the state of the cortex and behavioral performance in a visual detection task. We next identify neural and behavioral signatures of contextual modulation which are consistent with previously reported effects of spatial attention classically measured in primates. Finally, we follow visual signals along their feedforward path and determine how spatial context affects the propagation of visual signals to premotor areas. By making use of large-scale neural population recordings and well controlled quantitative behavioral tasks, we have begun to elucidate the mechanisms by which mice use spatial contextual cues to modulate visuomotor processing.
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2023-01-31
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