Thrombus Formation under High Shear in Arterial Stenotic Flow

Flannery, Conor James

Title:

Thrombus Formation under High Shear in Arterial Stenotic Flow

dc.contributor.advisor	Ku, David N.
dc.contributor.author	Flannery, Conor James	en_US
dc.contributor.committeeMember	Anes J. Garcia
dc.contributor.committeeMember	Larry V. McIntire
dc.contributor.department	Mechanical Engineering	en_US
dc.date.accessioned	2005-07-28T18:03:56Z
dc.date.available	2005-07-28T18:03:56Z
dc.date.issued	2005-04-28	en_US
dc.description.abstract	Acute thrombotic and thromboembolic occlusion of atherosclerotic vessels are events that precipitate most heart attacks and strokes. In arterial stenotic flow, thrombus formation is shear dependent and may or may not lead to complete occlusion of the vessel. Platelets in whole blood adhere to collagen-coated surfaces and as they accumulate the resistance of the stenosis increases because of the decreasing passageway of the occluded stenosis. As a model of blood clotting in stenoses, porcine blood is heparinized and perfused over tubular glass test sections that are coated with collagen type I. Each test section has a preexisting stenosis and its severity varies so that higher percent stenoses produce higher shear rates on the blood. The hypothesis of this thesis is that high shear rates due to stenosis in arteries are a necessary feature for occlusive thrombosis.	en_US
dc.description.degree	M.S.	en_US
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dc.format.mimetype	video/quicktime
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dc.format.mimetype	video/quicktime
dc.format.mimetype	video/quicktime
dc.format.mimetype	video/quicktime
dc.identifier.uri	http://hdl.handle.net/1853/6943
dc.language.iso	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.subject	Stenosis	en_US
dc.subject	Shear
dc.subject	Blood
dc.subject	Thrombosis
dc.title	Thrombus Formation under High Shear in Arterial Stenotic Flow	en_US
dc.type	Text
dc.type.genre	Thesis
dspace.entity.type	Publication
local.contributor.advisor	Ku, David N.
local.contributor.corporatename	George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename	College of Engineering
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