Title:
Thrombus Formation under High Shear in Arterial Stenotic Flow
Thrombus Formation under High Shear in Arterial Stenotic Flow
Author(s)
Flannery, Conor James
Advisor(s)
Ku, David N.
Editor(s)
Collections
Supplementary to
Permanent Link
Abstract
Acute thrombotic and thromboembolic occlusion of atherosclerotic vessels are events that precipitate most heart attacks and strokes. In arterial stenotic flow, thrombus formation is shear dependent and may or may not lead to complete occlusion of the vessel. Platelets in whole blood adhere to collagen-coated surfaces and as they accumulate the resistance of the stenosis increases because of the decreasing passageway of the occluded stenosis. As a model of blood clotting in stenoses, porcine blood is heparinized and perfused over tubular glass test sections that are coated with collagen type I. Each test section has a preexisting stenosis and its severity varies so that higher percent stenoses produce higher shear rates on the blood. The hypothesis of this thesis is that high shear rates due to stenosis in arteries are a necessary feature for occlusive thrombosis.
Sponsor
Date Issued
2005-04-28
Extent
1234075 bytes
7641818 bytes
4870938 bytes
4416989 bytes
2299041 bytes
2666037 bytes
7641818 bytes
4870938 bytes
4416989 bytes
2299041 bytes
2666037 bytes
Resource Type
Text
Resource Subtype
Thesis