The Role of Noise-Induced Excitable Dynamics of Rho Family GTPases in the Regulation of Actin Cytoskeleton

Rahman, Farhan S.

Title:

The Role of Noise-Induced Excitable Dynamics of Rho Family GTPases in the Regulation of Actin Cytoskeleton

dc.contributor.advisor	Tsygankov, Denis
dc.contributor.author	Rahman, Farhan S.
dc.contributor.committeeMember	Hladyshau, Siarhei
dc.contributor.department	Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned	2022-02-10T18:47:54Z
dc.date.available	2022-02-10T18:47:54Z
dc.date.created	2021-12
dc.date.issued	2021-12
dc.date.submitted	December 2021
dc.date.updated	2022-02-10T18:47:54Z
dc.description.abstract	Rho GTPases, a family of signaling proteins, play a pivotal role by acting as molecular switches to regulate F-actin cytoskeletal and cell adhesion. Recent studies have shown that reaction-diffusion (RD) models have the ability to exhibit a wide variety of characteristic patterns of wave propagations of Rho GTPases. This study uses computational modeling to investigate a particular dynamic behavior directly relevant to the observed protrusive activity of motile cells: a single decaying traveling wave of actin polymerization. The model is conducted in a 2D cell of an arbitrarily complex shape. It reveals that the inhibitor decay rate controls the transition from reflecting waves to a single decaying wave and helps to avoid the formation of spiral waves. For noise, we observe that it controls the propagation of wavefronts, such that higher amplitudes of noise induce a greater number of waves. Additionally, the model distinguishes that noise induces waves at different time points. These findings serve as a framework for further comprehensive representation of actin polymerization during cellular morphogenesis.
dc.description.degree	Undergraduate
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/1853/66265
dc.language.iso	en_US
dc.publisher	Georgia Institute of Technology
dc.subject	Rho gtpases
dc.subject	Reaction-diffusion
dc.subject	Computational modeling
dc.subject	noise
dc.subject	F-actin
dc.title	The Role of Noise-Induced Excitable Dynamics of Rho Family GTPases in the Regulation of Actin Cytoskeleton
dc.type	Text
dc.type.genre	Undergraduate Thesis
dspace.entity.type	Publication
local.contributor.corporatename	Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename	Undergraduate Research Opportunities Program
local.contributor.corporatename	College of Engineering
local.relation.ispartofseries	Undergraduate Research Option Theses
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relation.isOrgUnitOfPublication	0db885f5-939b-4de1-807b-f2ec73714200
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thesis.degree.level	Undergraduate