Title:
Microinjection Into Skin Using Microneedles

dc.contributor.advisor Prausnitz, Mark R.
dc.contributor.author Martanto, Wijaya en_US
dc.contributor.committeeMember Allen, Mark
dc.contributor.committeeMember Banga, Ajay
dc.contributor.committeeMember Sambanis, Athanassios
dc.contributor.committeeMember Smith, Marc
dc.contributor.department Chemical Engineering en_US
dc.date.accessioned 2006-09-01T19:47:36Z
dc.date.available 2006-09-01T19:47:36Z
dc.date.issued 2005-06-06 en_US
dc.description.abstract The development of microneedles that penetrate the skin barrier, but are small enough not to stimulate nerves, has the potential to deliver drugs across skin in a painless way. Controlled injection by convective flow into skin using hollow microneedles, however, has remained a challenge. To address this challenge, the goals of this study were (i) to provide experimental measurements coupled with numerical simulations to quantitatively describe fluid mechanics of flow within microneedles over a range of experimental conditions and needle geometries, (ii) to demonstrate and study the effects of diffusion-based delivery of insulin to diabetic rats in vivo using solid and hollow microneedles and (iii) to determine the effect of experimental parameters on microinfusion through hollow microneedles into skin to optimize drug delivery protocols and identify rate-limiting barriers to flow. Experimentally, we quantified the relationship between pressure drop and flow rate through microneedles as a function of fluid viscosity and microneedle length, diameter, and cone half-angle. Microneedle tip diameter and taper angle were the primary controlling parameters for flow through conically tapered microneedles as shown by numerical simulations. Flow rates over a range of 1.4 56 l/s were achieved through microneedles (in the absence of skin) with pressure drops in the range of 4.6 196.5 kPa. This work also studied the use of solid and hollow microneedle arrays to insert into the skin of diabetic animals for transdermal delivery of insulin. Blood glucose levels dropped by as much as 80% in diabetic rats in vivo. Larger drops in blood glucose level and larger plasma insulin concentrations were shown due to higher donor solution insulin concentration, shorter microneedles insertion time and fewer repeated insertions. The final scope of this work was to determine the effect of microneedle geometry and infusion protocols on microinfusion flow rate into skin in vitro. Infusion flow rates ranged from 21 to 1130 l/h was demonstrated using glass microneedles. The presence of a bevel at the microneedle tip, larger retraction distance and insertion depth, larger infusion pressure and the presence of hyaluronidase led to larger infusion flow rates. en_US
dc.description.degree Ph.D. en_US
dc.format.extent 3171500 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/11645
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Hollow needle en_US
dc.subject Microfluidics
dc.subject Bevel needle
dc.subject Solid needle
dc.title Microinjection Into Skin Using Microneedles en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Prausnitz, Mark R.
local.contributor.corporatename School of Chemical and Biomolecular Engineering
local.contributor.corporatename College of Engineering
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relation.isOrgUnitOfPublication 6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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