Nano and Micromechanics of Biological Tissues

Dean, Delphine

Title:

Nano and Micromechanics of Biological Tissues

dc.contributor.author	Dean, Delphine
dc.contributor.corporatename	Georgia Institute of Technology. Nanotechnology Research Center
dc.contributor.corporatename	Clemson University
dc.date.accessioned	2012-04-03T20:20:28Z
dc.date.available	2012-04-03T20:20:28Z
dc.date.issued	2012-03-13
dc.description	Delphine Dean presented a lecture at the Nano@Tech Meeting on March 13, 2012 at 12 noon in room 1116 of the Marcus Nanotechnology Building.	en_US
dc.description	Dr. Delphine Dean is assistant professor of bioengineering at Clemson University. She earned her Ph.D. in Electrical Engineering and Computer Science from MIT in 2005 and started her faculty position at Clemson in January 2007. Her lab leads a wide range of studies focused on understanding mechanics and interactions of biological systems across length scales. Her expertise is in nano- to micro-scale characterization of biological tissues including experimental techniques such as atomic force microscopy and mathematical modeling such as finite element analysis. Some of her prior work has focused on cartilage macromolecular interactions and characterizing the effect of the microenvironment on cardiovascular cell mechanical properties and, more recently, she has led several studies investigating the use of dental pulp stem cells for tissue engineering applications.
dc.description	Runtime: 51:50 minutes
dc.description.abstract	Using a variety of experimental techniques and modeling approaches, the mechanical properties of biological tissues can be characterized over a large range of length scales. One can look at interactions between molecules (nanoscale), cellular mechanics (microscale), or bulk tissue properties (macroscale). In this talk, I will discuss several projects in which the nanomechanical properties and interactions of a variety of biological tissues are characterized. We will discuss several results where we characterized directly individual cardiovascular cell mechanical properties as a function of microenvironment. We used atomic force microscopy (AFM) in conjunction with confocal microscopy to directly measure cell mechanical properties and interactions. For instance, we measured the effect of matrix composition and structure on cardiac cell mechanical properties in vitro. The extracellular matrix can modulate cell mechanical properties and these microenvironmental cues can lead to changes in cell phenotype and function. In our study, cells were shown to stiffen depending on the type of the underlying protein (e.g., collagen vs. fibronectin) as well as whether the matrix was randomly oriented or aligned. By creating engineered microenvironments using lithographic and nanoparticle techniques, we can design experiments that will determine the dependence of cell mechanical function on environmental factors. Our eventual goal is to build better models of the cardiac and vascular cell mechanical environment.	en_US
dc.format.extent	51:50 minutes
dc.identifier.uri	http://hdl.handle.net/1853/43176
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	Nano@Tech Lecture Series
dc.subject	Atomic force microscopy	en_US
dc.subject	Biomechanics	en_US
dc.subject	Cardiovascular	en_US
dc.subject	Nanomechanics	en_US
dc.subject	Nanotechnology	en_US
dc.title	Nano and Micromechanics of Biological Tissues	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	Institute for Electronics and Nanotechnology (IEN)
local.relation.ispartofseries	Nano@Tech Lecture Series
relation.isOrgUnitOfPublication	5d316582-08fe-42e1-82e3-9f3b79dd6dae
relation.isSeriesOfPublication	accfbba8-246e-4389-8087-f838de8956cf