Title:
Combined Micro and Nanopatterning for Cell Substrates

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dc.contributor.advisor King, William P.
dc.contributor.author Eliason, Marcus Todd en_US
dc.contributor.committeeMember Anes J. Garcia
dc.contributor.committeeMember Graham, Samuel
dc.contributor.department Mechanical Engineering en_US
dc.date.accessioned 2007-05-25T17:29:07Z
dc.date.available 2007-05-25T17:29:07Z
dc.date.issued 2007-04-09 en_US
dc.description.abstract The success of many emerging biotechnologies depends upon the ability to tune cell function to mimic conditions found in vivo. Cells exhibit complex interactions with their surrounding environment known and the extracellular matrix (ECM). These interactions control many cell functions such as proliferation, differentiation and cell death. ECM components span the meso-, micro- and nano-length scales. Successful biotechnologies therefore must also exhibit patterning over these length scales. The objective of this study is to fabricate and analyze cell response to micro and nanopatterned polymer substrates. Experiments examined cell alignment and proliferation to various substrates. The substrates used featured micropatterned grooves and holes, micropatterned carbon nanotubes, and combinations of microgrooves and nanogrooves. Results showed significant interactions between cell alignment and the patterned topography for all substrate types, while cell proliferation showed no significant dependence on these topographic parameters. en_US
dc.description.degree M.S. en_US
dc.identifier.uri http://hdl.handle.net/1853/14539
dc.publisher Georgia Institute of Technology en_US
dc.subject Micropatterning en_US
dc.subject Cell response en_US
dc.subject Nanopatterning en_US
dc.title Combined Micro and Nanopatterning for Cell Substrates en_US
dc.type Text
dc.type.genre Thesis
dspace.entity.type Publication
local.contributor.corporatename George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename College of Engineering
relation.isOrgUnitOfPublication c01ff908-c25f-439b-bf10-a074ed886bb7
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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