Title:
TP508 maintains chondrocyte cell viability through blocking apoptosis in an NO-dependent manner

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dc.contributor.advisor Boyan, Barbara D.
dc.contributor.author Zhong, Ming en_US
dc.contributor.committeeMember Jo, Hanjoong
dc.contributor.committeeMember Zvi, Schwartz
dc.contributor.department Biomedical Engineering en_US
dc.date.accessioned 2008-02-07T18:38:54Z
dc.date.available 2008-02-07T18:38:54Z
dc.date.issued 2006-11-27 en_US
dc.description.abstract TP508 is a 23 amino acid peptide derived from human prothrombin. It helps wound healing in both soft tissues and bones. In our previous study, we have demonstrated that TP508 retains chondrocyte in a less mature differentiation state while expanding the cartilage mass, indicating it may partly help bone healing by expand the cartilage template in the endochondral bone formation stage. In our current study, we want to demonstrate that TP508 also blocks chondrocyte apoptosis. We used rat costochondral growth plate chondrocytes as our model. We first established chelerythrine as an apoptogen in chondrocytes. TP508 is able to block apoptosis caused by chelerythrine. Chelerythrine also causes an increase in NO production, which is known to cause both pathological and physiological apoptosis of chondrocyte, and blocking NO production can in turn block apoptosis caused by them. TP508 is also able to block NO production caused by chelerythrine. Therefore, TP508 may partially block chondrocyte apoptosis by blocking NO production. From all above, we conclude that besides decreasing chondrocyte differentiation, TP508 also blocks their apoptosis, so as to conserve the cartilage template in endochondral bone formation en_US
dc.description.degree M.S. en_US
dc.identifier.uri http://hdl.handle.net/1853/19800
dc.publisher Georgia Institute of Technology en_US
dc.subject Bone fracture healing en_US
dc.subject Chondrocyte en_US
dc.subject NO en_US
dc.subject Growth plate en_US
dc.subject TP508 en_US
dc.subject.lcsh Amino acids
dc.subject.lcsh Peptides
dc.subject.lcsh Wound healing
dc.subject.lcsh Cartilage cells
dc.subject.lcsh Apoptosis
dc.subject.lcsh Nitric oxide
dc.title TP508 maintains chondrocyte cell viability through blocking apoptosis in an NO-dependent manner en_US
dc.type Text
dc.type.genre Thesis
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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