Title:
A temperature-controlled glove with non-invasive arterial pulse sensing for active neuro-vascular assessment

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Carek, Andrew
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Inan, Omer T.
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Abstract
The objective of the proposed research is to develop a non-invasive, active neuro-vascular assessment system using a modified temperature-controlled glove and feedback techniques. The glove incorporates local heating and cooling of the hand using multi-point skin temperature measurements as feedback, and thereby induces local and central mechanisms involved in thermoregulation. Biosensors were used to monitor electrophysiology and hemodynamic changes in response to temperature modulation. Then, the triggered neuro-vascular mechanisms associated with thermoregulation were quantified by extracting parameters from the measured waveforms, specifically heart rate variability (HRV), vascular tone, and BP. The system was tested on six young, healthy individuals with no history of microvascular diseases. Both heating and cooling resulted in changes that would be expected physiologically in passive experiments; however, the ability to actively modulate the physiology non-invasively with a controlled, quantitative, and inexpensive instrument can potentially enable serial assessments of neuro-vascular control outside of clinical settings.
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2016-12-08
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