Title:
Protein Association in Dilute and Crowded Solutions

dc.contributor.author Zhou, Huan-Xiang en_US
dc.contributor.corporatename Florida State University en_US
dc.contributor.corporatename Georgia Institute of Technology. School of Physics en_US
dc.date.accessioned 2011-11-29T20:50:56Z
dc.date.available 2011-11-29T20:50:56Z
dc.date.issued 2011-11-09
dc.description Presented on November 9, 2011 from 3:00 pm to 4:00 pm In Howey building room L5. en_US
dc.description Runtime: 54:58 minutes en_US
dc.description.abstract Most biological processes are mediated by mediated by protein association, and often are under kinetic rather than thermodynamic control. We have developed the transient-complex theory for protein association, which presents a framework for elucidating the mechanisms of protein association and for predicting the association rates. The transient complex refers to an intermediate along the association process, in which the two associating molecules have near-native separation and relative orientation but have yet to form the short-range specific interactions of the native complex. Our theory rationalizes the variations in association rates over 10 orders of magnitudes and gives accurate prediction of the association rates based on the structures of the native complexes. In the cellular context, association processes occur in the presence of a high concentration of background macromolecules. We have developed methods to model the effects of the crowded cellular environments on the affinities and rate constants of protein association. These studies allow us to achieve a quantitative understanding of biological processes in the cellular context, based on fundamental physical principles. en_US
dc.format.extent 54:58 minutes
dc.identifier.uri http://hdl.handle.net/1853/42017
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries Physics Colloquium
dc.subject Physics colloquia en_US
dc.subject Protein association en_US
dc.subject Solutions en_US
dc.subject Crowded cellular environments en_US
dc.subject Kinetics en_US
dc.title Protein Association in Dilute and Crowded Solutions en_US
dc.type Moving Image
dc.type.genre Lecture
dspace.entity.type Publication
local.contributor.corporatename College of Sciences
local.contributor.corporatename School of Physics
local.relation.ispartofseries Physics Colloquium
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
relation.isOrgUnitOfPublication 2ba39017-11f1-40f4-9bc5-66f17b8f1539
relation.isSeriesOfPublication 5fcf4984-0912-45ae-91c5-2c6de98772b0
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