In vitro micro particle image velocimetry measurements in the hinge region of a bileaflet mechanical heart valve

Jun, Brian H.

Title:

In vitro micro particle image velocimetry measurements in the hinge region of a bileaflet mechanical heart valve

dc.contributor.advisor	Yoganathan, Ajit P.
dc.contributor.author	Jun, Brian H.
dc.contributor.committeeMember	Dixon, Brandon
dc.contributor.committeeMember	Giddens, Don P.
dc.contributor.department	Mechanical Engineering
dc.date.accessioned	2015-06-08T18:00:19Z
dc.date.available	2015-06-09T05:30:06Z
dc.date.created	2014-05
dc.date.issued	2014-04-09
dc.date.submitted	May 2014
dc.date.updated	2015-06-08T18:00:19Z
dc.description.abstract	A number of clinical, in vitro and computational studies have shown the potential for thromboembolic complications in bileaflet mechanical heart valves (BMHV), primarily due to the complex and unsteady flows in the valve hinges. These studies have focused on quantitative and qualitative parameters such as velocity magnitude, turbulent shear stresses, vortex formation and platelet activation to identify potential for blood damage. However, experimental characterization of the whole flow fields within the valve hinges has not yet been conducted. This information can be utilized to investigate instantaneous damage to blood elements and also to validate numerical studies focusing on the hinge’s complex fluid dynamics. The objective of this study was therefore to develop a high-resolution imaging system to characterize the flow fields and global velocity maps in a BMHV hinge. Subsequently, the present study investigated the effect of hinge gap width on flow fields in a St. Jude Medical BMHV. The results from this study suggest that the BMHV hinge design is a delicate balance between reduction of fluid shear stresses and areas of flow stasis during leakage flow, and needs to be optimized to ensure minimal thromboembolic complications. Overall, the current study demonstrates the ability of high-resolution Micro Particle Image Velocimetry to assess the fluid flow fields within the hinges of bileaflet mechanical heart valves, which can be extended to investigate micro-scale flow domains in critical regions of other cardiovascular devices to assess their blood damage potential.
dc.description.degree	M.S.
dc.embargo.terms	2015-05-01
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/1853/53380
dc.language.iso	en_US
dc.publisher	Georgia Institute of Technology
dc.subject	Thrombosis
dc.subject	Blood damage
dc.subject	Hinge flow
dc.subject	Fluid dynamics
dc.subject	Particle image velocimetry (PIV)
dc.subject	Mechanical heart valve (MHV)
dc.title	In vitro micro particle image velocimetry measurements in the hinge region of a bileaflet mechanical heart valve
dc.type	Text
dc.type.genre	Thesis
dspace.entity.type	Publication
local.contributor.advisor	Yoganathan, Ajit P.
local.contributor.corporatename	George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename	College of Engineering
relation.isAdvisorOfPublication	6a910742-4bed-4ba6-b03d-f92e4c915a00
relation.isOrgUnitOfPublication	c01ff908-c25f-439b-bf10-a074ed886bb7
relation.isOrgUnitOfPublication	7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level	Masters