Title:
Influence of static and dynamic topography on osteoblast proliferation and maturation

dc.contributor.advisor Boyan, Barbara D.
dc.contributor.author Lee, Erin Marie
dc.contributor.committeeMember Bellamkonda, Ravi
dc.contributor.committeeMember Chen, Haifeng
dc.contributor.committeeMember Gall, Ken
dc.contributor.committeeMember Temenoff, Johnna
dc.contributor.committeeMember Zhu, Cheng
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2017-01-11T14:03:52Z
dc.date.available 2017-01-11T14:03:52Z
dc.date.created 2016-12
dc.date.issued 2016-11-15
dc.date.submitted December 2016
dc.date.updated 2017-01-11T14:03:52Z
dc.description.abstract Osseointegration remains a primary concern for implanted devices in patients with risk factors such as diabetes, smoking, age, arthritis, and osteoporosis. Current use of titanium alloys, while successful, comes at a high cost. Cheaper alternatives may exist with polymers for some non-load bearing applications. Advancements in polymer chemistry have yielded a class of smart materials called shape-memory polymers (SMPs), which can change their shape via changes in temperature or mechanical stress. This study follows the creation of one such temperature-sensitive SMP, benzyl acrylate-benzyl methacrylate-1,12-dodecanediol dimethacrylate, which can be compressed to remove all surface topography and at 37˚C shows nearly complete recovery within 8 hours. The examination of pre-osteoblast MG63 cell behavior on these SMPs (with and without compression) by DNA and ELISAs indicates MG63 cells can be 'clued' to proliferate and then to rapidly mature. Similar topography was created on polymers of varied stiffness to determine if there is correlation between substrate stiffness and topography on osteoblast maturation. Overall, this thesis gives insight into potential benefits of SMP use in biomedical applications. In addition, it demonstrates the potential issues concerning the use of polymers to achieve a desires cell response.
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/56296
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject MG63 human osteoblast-like cells
dc.subject Shape-memory polymer
dc.subject Surface roughness
dc.subject Biomaterials
dc.title Influence of static and dynamic topography on osteoblast proliferation and maturation
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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