Title:
Expanding the role of functional mri in rehabilitation research

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dc.contributor.advisor Hu, Xiaoping
dc.contributor.author Glielmi, Christopher B. en_US
dc.contributor.committeeMember Benkeser, Paul
dc.contributor.committeeMember Keilholz, Shella
dc.contributor.committeeMember Sathian, Krish
dc.contributor.committeeMember Schuchard, Ronald
dc.contributor.department Biomedical Engineering en_US
dc.date.accessioned 2010-06-10T17:01:57Z
dc.date.available 2010-06-10T17:01:57Z
dc.date.issued 2009-04-06 en_US
dc.description.abstract Functional magnetic resonance imaging (fMRI) based on blood oxygenation level dependent (BOLD) contrast has become a universal methodology in functional neuroimaging. However, the BOLD signal consists of a mix of physiological parameters and has relatively poor reproducibility. As fMRI becomes a prominent research tool for rehabilitation studies involving repeated measures of the human brain, more quantitative and stable fMRI contrasts are needed. This dissertation enhances quantitative measures to complement BOLD fMRI. These additional markers, cerebral blood flow (CBF) and cerebral blood volume (CBV) (and hence cerebral metabolic rate of oxygen (CMRO₂) modeling) are more specific imaging markers of neuronal activity than BOLD. The first aim of this dissertation assesses feasibility of complementing BOLD with quantitative fMRI measures in subjects with central visual impairment. Second, image acquisition and analysis are developed to enhance quantitative fMRI by quantifying CBV while simultaneously acquiring CBF and BOLD images. This aim seeks to relax assumptions related to existing methods that are not suitable for patient populations. Finally, CBF acquisition using a low-cost local labeling coil, which improves image quality, is combined with simultaneous acquisition of two types of traditional BOLD contrast. The demonstrated enhancement of CBF, CBV and CMRO₂measures can lead to better characterization of pathophysiology and treatment effects. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/33972
dc.publisher Georgia Institute of Technology en_US
dc.subject Rehabilitation en_US
dc.subject Cerebral blood flow en_US
dc.subject Cerebral blood volume en_US
dc.subject Blood oxygenation level dependent en_US
dc.subject Cerebral metabolic rate of oxygen en_US
dc.subject Vascular space occupancy en_US
dc.subject Low vision en_US
dc.subject.lcsh Cerebral circulation
dc.subject.lcsh Blood Circulation
dc.subject.lcsh Magnetic resonance imaging
dc.subject.lcsh Rehabilitation Research
dc.subject.lcsh Cerebral circulation Imaging
dc.subject.lcsh Diagnostic imaging
dc.title Expanding the role of functional mri in rehabilitation research en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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