Title:
The design of multifunctional hydrogel nanoparticles for drug delivery

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dc.contributor.advisor Lyon, L. Andrew
dc.contributor.author Smith, Michael Hughes en_US
dc.contributor.committeeMember Anselm Griffin
dc.contributor.committeeMember Facundo Fernandez
dc.contributor.committeeMember Janata, Jiri
dc.contributor.committeeMember Dickson, Robert M.
dc.contributor.department Chemistry and Biochemistry en_US
dc.date.accessioned 2012-06-06T16:42:59Z
dc.date.available 2012-06-06T16:42:59Z
dc.date.issued 2012-02-23 en_US
dc.description.abstract Hydrogel micro- and nanoparticles (microgels and nanogels) are a promising class of drug delivery vehicles. Composed of hydrophilic polymers arranged into a cross-linked network structure, nanogels show several attractive features for the delivery of macromolecule therapeutics. For instance, the hydrated, porous internal cavity of the nanogel may serve as a high capacity compartment for loading macromolecules, whereas the periphery of the nanogel may be used as a scaffold for conjugating cell-specific targeting moieties. This dissertation presents recent investigations of nanogels as targeted delivery vehicles for oligonucleotides to cancer cells, while exploring new nanogel chemistries that enable future in vivo applications. For instance, synthetic efforts have produced particles capable of erosion into low molar mass constituents, providing a possible mechanism of particle clearance after repeated administration in vivo. In another example, the microgel network chemistry was tuned to promote the encapsulation of charged proteins. In parallel with those synthetic efforts, new light scattering methodologies were developed to accurately quantify the particle behaviors (e.g. loading, erosion). Using multiangle light scattering (MALS), changes in particle molar mass and radius were measured, providing a quantitative and direct approach for monitoring nanogel erosion and macromolecule encapsulation. The new particle chemistries demonstrated, together with enabling light scattering methods, will catalyze the development of improved delivery vehicles in the near future. en_US
dc.description.degree PhD en_US
dc.identifier.uri http://hdl.handle.net/1853/43609
dc.publisher Georgia Institute of Technology en_US
dc.subject Light scattering en_US
dc.subject SiRNA en_US
dc.subject RNA interference en_US
dc.subject Microgel en_US
dc.subject Drug delivery en_US
dc.subject Hydrogel particle en_US
dc.subject Nanogel en_US
dc.subject.lcsh Drug delivery systems
dc.subject.lcsh Nanogels
dc.subject.lcsh Colloids
dc.subject.lcsh Nanostructured materials
dc.title The design of multifunctional hydrogel nanoparticles for drug delivery en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Lyon, L. Andrew
local.contributor.corporatename School of Chemistry and Biochemistry
local.contributor.corporatename College of Sciences
relation.isAdvisorOfPublication 6a99c0e3-9c1a-4564-ad17-9be174626f75
relation.isOrgUnitOfPublication f1725b93-3ab8-4c47-a4c3-3596c03d6f1e
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
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