Title:
Design, fabrication and testing of an acoustic resonator-based biosensor for the detection of cancer biomarkers

Simple item page
dc.contributor.advisor Hunt, William D.
dc.contributor.author Dickherber, Anthony en_US
dc.contributor.committeeMember Alfred Merrill, Jr.
dc.contributor.committeeMember John Petros
dc.contributor.committeeMember Peter Hesketh
dc.contributor.committeeMember Butera, Robert
dc.contributor.department Electrical and Computer Engineering en_US
dc.date.accessioned 2009-01-22T15:47:10Z
dc.date.available 2009-01-22T15:47:10Z
dc.date.issued 2008-11-10 en_US
dc.description.abstract The objective of this thesis research is to develop microelectronic acoustic technology towards biosensor applications. The development of a simple and robust resonator that employs simple microelectronic fabrication techniques for its construction could provide the foundation for a cost-effective sensor platform. Subsequent development of an appropriate surface chemistry treatment would functionalize the resonator as a biosensor. Implementation of this design in an array configuration allows for the development of ligand microarrays, which subsequently allows for multi-ligand recognition signatures as well as testing redundancy. The applications for such a tool extend to a myriad of applications, but the focus of this research is to develop this technology towards an early cancer detection capability. Specifically, I develop a solidly-mounted resonator with thin-film ZnO as my active piezoelectric layer. These resonators undergo an extensive development process to arrive at a final device design and are fully characterized throughout by X-ray diffraction and scattering analysis. Employing silane chemistry, these resonators are functionalized as immunosensors by covalently binding antibodies to the surface of the device. The quality of the surface chemistry is fully assessed using water contact angle, atomic force microscopy and confocal laser scanning microscopy. Functionalized biosensors are then used to quantify the concentration of known proteins marker in both a purified medium and a physiologically-relevant medium. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/26575
dc.publisher Georgia Institute of Technology en_US
dc.subject Solidly mounted resonator en_US
dc.subject Organosilane en_US
dc.subject Prostate cancer en_US
dc.subject ZnO en_US
dc.subject Biosensor en_US
dc.subject Thin film resonator en_US
dc.subject.lcsh Biosensors
dc.subject.lcsh Cancer
dc.subject.lcsh Microelectronics
dc.subject.lcsh Proteomics
dc.subject.lcsh Molecular diagnosis
dc.title Design, fabrication and testing of an acoustic resonator-based biosensor for the detection of cancer biomarkers en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Hunt, William D.
local.contributor.corporatename School of Electrical and Computer Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 8dfe8c09-39f6-4895-9ac7-547efb52a173
relation.isOrgUnitOfPublication 5b7adef2-447c-4270-b9fc-846bd76f80f2
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
dickherber_anthony_j_200812_phd.pdf
Size:
6.63 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Theses and Dissertations