Bringing Bioelectricity to Light

Cohen, Adam

Title:

Bringing Bioelectricity to Light

dc.contributor.author	Cohen, Adam
dc.contributor.corporatename	Georgia Institute of Technology. Neural Engineering Center	en_US
dc.contributor.corporatename	Harvard University. Dept. of Physics	en_US
dc.contributor.corporatename	Harvard University. Dept. of Chemistry	en_US
dc.date.accessioned	2017-02-14T19:25:21Z
dc.date.available	2017-02-14T19:25:21Z
dc.date.issued	2017-02-06
dc.description	Presented on February 6, 2017 at 11:00 a.m. in the Engineered Biosystems Building, Room 1005.	en_US
dc.description	Adam Cohen is Professor of Chemistry and Chemistry Biology and of Physics at Harvard University. His research focuses on developing and applying new physical tools to probe molecules and cells, with project ranging from quantum mechanics to pure biology.	en_US
dc.description	Runtime: 57:34 minutes	en_US
dc.description.abstract	To study a neural circuit, one would like to probe the activity of many neurons, with high resolution in space and time. A key challenge has been the difficulty of visualizing changes in transmembrane potential. We discovered that a protein derived from a Dead Sea microorganism could function as an exquisitely fast and sensitive fluorescent reporter of membrane voltage. We developed optical tools for simultaneous optical perturbation and optical readout of membrane voltage. Using these tools we have studied electrical activity in primary neurons in vitro, in acute brain slice, and in live mice. We have also studied human iPSC-based neuronal models of diseases such as pain, epilepsy, and ALS. Optical electrophysiology provides new insights into these complex bioelectric phenomena.	en_US
dc.format.extent	57:34 minutes
dc.identifier.uri	http://hdl.handle.net/1853/56443
dc.language.iso	en_US	en_US
dc.relation.ispartofseries	GT Neuro Seminar Series
dc.subject	Optical electrophysiology	en_US
dc.subject	Optogenetics	en_US
dc.title	Bringing Bioelectricity to Light	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	Neural Engineering Center
local.relation.ispartofseries	GT Neuro Seminar Series
relation.isOrgUnitOfPublication	c2e26044-257b-4ef6-8634-100dd836a06c
relation.isSeriesOfPublication	608bde12-7f29-495f-be22-ac0b124e68c5