Title:
Harnessing systems biology approaches to engineer functional microvascular networks

dc.contributor.author Sefcik, Lauren S. en_US
dc.contributor.author Wilson, Jennifer L. en_US
dc.contributor.author Papin, Jason A. en_US
dc.contributor.author Botchwey, Edward A. en_US
dc.contributor.corporatename Lafayette College. Dept. of Chemical and Biomolecular Engineering en_US
dc.contributor.corporatename University of Virginia. Dept. of Biomedical Engineering en_US
dc.contributor.corporatename University of Virginia. Robert M. Berne Cardiovascular Research Center en_US
dc.contributor.corporatename University of Virginia. Dept. of Orthopaedic Surgery en_US
dc.contributor.corporatename University of Virginia. Center for Immunity, Inflammation, and Regenerative Medicine en_US
dc.date.accessioned 2013-06-13T17:29:38Z
dc.date.available 2013-06-13T17:29:38Z
dc.date.issued 2010
dc.description This is a copy of an article published in Tissue Engineering Part B. © 2010 Mary Ann Liebert, Inc.; Tissue Engineering Part B is available online at: http://online.liebertpub.com en_US
dc.description DOI: 10.1089/ten.teb.2009.0611 en_US
dc.description.abstract Microvascular remodeling is a complex process that includes many cell types and molecular signals. Despite a continued growth in the understanding of signaling pathways involved in the formation and maturation of new blood vessels, approximately half of all compounds entering clinical trials will fail, resulting in the loss of much time, money, and resources. Most pro-angiogenic clinical trials to date have focused on increasing neovascularization via the delivery of a single growth factor or gene. Alternatively, a focus on the concerted regulation of whole networks of genes may lead to greater insight into the underlying physiology since the coordinated response is greater than the sum of its parts. Systems biology offers a comprehensive network view of the processes of angiogenesis and arteriogenesis that might enable the prediction of drug targets and whether or not activation of the targets elicits the desired outcome. Systems biology integrates complex biological data from a variety of experimental sources (-omics) and analyzes how the interactions of the system components can give rise to the function and behavior of that system. This review focuses on how systems biology approaches have been applied to microvascular growth and remodeling, and how network analysis tools can be utilized to aid novel pro-angiogenic drug discovery. en_US
dc.identifier.citation Sefcik, L.S., Wilson, J.L., Papin, K.A., Botchwey, E.A., "Harnessing systems biology approaches to engineer functional microvascular networks," Tissue Engineering Part B, 16,3, 361-370 (2010) en_US
dc.identifier.doi 10.1089/ten.teb.2009.0611
dc.identifier.issn 1937-3368
dc.identifier.uri http://hdl.handle.net/1853/47468
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.publisher.original Mary Ann Liebert, Inc. en_US
dc.subject Microvascular remodeling en_US
dc.subject Tissue engineering en_US
dc.subject Microvascular networks en_US
dc.title Harnessing systems biology approaches to engineer functional microvascular networks en_US
dc.type Text
dc.type.genre Article
dspace.entity.type Publication
local.contributor.author Botchwey, Edward A.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAuthorOfPublication 748632d9-c271-435b-84cf-3cc1e5965684
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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