MECHANICALLY MEDIATED GROWTH AND REMODELING OF COLLECTING LYMPHATIC VESSELS

Sayed Razavi Rizi, Mohammad

Title:

MECHANICALLY MEDIATED GROWTH AND REMODELING OF COLLECTING LYMPHATIC VESSELS

dc.contributor.advisor	Gleason, Rudolph L.
dc.contributor.advisor	Dixon, J. Brandon
dc.contributor.author	Sayed Razavi Rizi, Mohammad
dc.contributor.committeeMember	Alexeev, Alexander
dc.contributor.committeeMember	Sun, Wei
dc.contributor.committeeMember	Zawieja, David C.
dc.contributor.department	Mechanical Engineering
dc.date.accessioned	2021-01-11T17:06:38Z
dc.date.available	2021-01-11T17:06:38Z
dc.date.created	2019-12
dc.date.issued	2020-08-31
dc.date.submitted	December 2019
dc.date.updated	2021-01-11T17:06:38Z
dc.description.abstract	Lymphatic dysfunction plays a key role in pathologies such as immune disorders, infection, cancer, obesity, and cardiovascular disease; regarding the latter, lymphatic dysfunction may exacerbate edema in myocardial infarction (MI) and chronic heart failure. Secondary lymphedema is a progressive and debilitating disease characterized by fluid retention and tissue swelling that can arise due to dysfunction in lymphatic pumping. Secondary lymphedema is a common complication in breast cancer treatment where the surgical removal of lymphatic vessels/lymph nodes can induce overloads that triggers lymphatic pathologies that can present months or even years after surgery. Although the local mechanical environment is known to regulate lymphatic function, the role of sustained mechanical overloads (e.g., high pressure and high flow) in lymphatic dysfunction has yet to be established. Towards this end, our long-term goal was to develop a mechanistic understanding of mechanically-mediated growth and remodeling (G&R) of collecting lymphatic vessels in health and disease and to ultimately identify novel therapeutic interventions to minimize the risk of occurrence, severity, or complications of lymphatic dysfunction. This PhD thesis focuses on developing a novel rat tail model to study lymphatic G&R and to employ a combined experimental-computational approach to quantify the modes by which sustained high pressure and high flow compromise the normal function of the lymphatic system via maladaptive remodeling. First, we introduced and used a novel rat tail model to study the effect of mechanical loads (specifically axial stretch) on the lymphatic contractility. Second, we developed a computational framework to study lymphatic pumping in the context of a lymphangion chain. Lastly, we developed and tested the feasibility of a novel lymphatic ligation model to study lymphatic remodeling post-surgery. Lastly, the methods and results from this study can pave the way for future studies of lymphatic remodeling in health and disease.
dc.description.degree	Ph.D.
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/1853/64035
dc.language.iso	en_US
dc.publisher	Georgia Institute of Technology
dc.subject	lymphatic system
dc.subject	lymphedema
dc.title	MECHANICALLY MEDIATED GROWTH AND REMODELING OF COLLECTING LYMPHATIC VESSELS
dc.type	Text
dc.type.genre	Dissertation
dspace.entity.type	Publication
local.contributor.advisor	Dixon, J. Brandon
local.contributor.advisor	Gleason, Rudolph L.
local.contributor.corporatename	George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename	College of Engineering
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thesis.degree.level	Doctoral