Title:
Identifying Promoters of Hepatic Regeneration in Zebrafish (Danio rerio) Following an Acetaminophen Liver Ablation

dc.contributor.advisor Montoya, Joseph P.
dc.contributor.author Dattilo, Zachary
dc.contributor.committeeMember Shin, Chong
dc.contributor.committeeMember Brockett, Mirjana
dc.contributor.department Biology
dc.date.accessioned 2015-08-19T17:21:03Z
dc.date.available 2015-08-20T05:30:08Z
dc.date.created 2014-05
dc.date.issued 2013-12-12
dc.date.submitted May 2014
dc.date.updated 2015-08-19T17:21:03Z
dc.description.abstract Identifying chemicals that can promote regeneration in damaged liver tissue could be critical for curing various liver diseases and accelerating the healing of liver damage. In order to study the regeneration of developing livers in zebrafish, acetaminophen was explored as a possible method for liver ablation. A chemical screening of over 250 novel compounds with unknown cellular targets and 75 compounds with stem cell targets was performed in order to identify some promising promoters of regeneration. Acetaminophen was found to successfully destroy the liver tissue of developing embryos, demonstrating its usefulness as a method of ablation in order to study regeneration. The chemical screening revealed several novel compounds and cell signalling pathways that show promise for successfully promoting liver regeneration.
dc.description.degree Undergraduate
dc.embargo.terms 2015-05-01
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/53758
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Zebrafish
dc.subject Liver
dc.subject Regeneration
dc.subject Acetaminophen
dc.title Identifying Promoters of Hepatic Regeneration in Zebrafish (Danio rerio) Following an Acetaminophen Liver Ablation
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.advisor Montoya, Joseph P.
local.contributor.corporatename College of Sciences
local.contributor.corporatename School of Biological Sciences
local.contributor.corporatename Undergraduate Research Opportunities Program
local.relation.ispartofseries Undergraduate Research Option Theses
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thesis.degree.level Undergraduate
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