The Effects of 40 Hz Sensory Stimulation on Amyloid Pathology in Hippocampal Area CA3 of a Mouse Model of Alzheimer's Disease
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Jones, Madison Lee
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Abstract
Alzheimer's Disease (AD) is a neurodegenerative condition ravaging cognition and causing memory loss. A 40 Hz flashing light, known as flicker, is a novel, noninvasive potential treatment for Alzheimer's Disease. In AD rodent models, flicker is known to modulate neural rhythms important for learning and memory. In hippocampal CA3, a region specific for learning and memory, flicker was administered and the cellular pathology was investigated. The immune response from microglia and toxic plaques of AD, known as amyloid beta, were quantified and analyzed after a 7-day exposure period to flicker in rodent AD models. No significant results were found after flicker administration, as the microglia and amyloid counts were similar across both groups. This may have resulted from the tissue undergoing extra stress from the extracellular recordings and probes in CA3 tissue.
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Undergraduate Research Option Thesis