Title:
Multi-scale structural design of titanium implants for improved osseointegration

dc.contributor.advisor Boyan, Barbara D.
dc.contributor.advisor Zhu, Cheng
dc.contributor.author Cheng, Alice
dc.contributor.committeeMember Schwartz, Zvi
dc.contributor.committeeMember Chen, Haifeng
dc.contributor.committeeMember Roy, Krishnendu
dc.contributor.committeeMember Sandhage, Kenneth H
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2017-01-11T14:03:27Z
dc.date.available 2017-01-11T14:03:27Z
dc.date.created 2016-12
dc.date.issued 2016-11-07
dc.date.submitted December 2016
dc.date.updated 2017-01-11T14:03:27Z
dc.description.abstract Osseointegration success of bone-interfacing implants is reduced for many compromised patients, necessitating improved implant design. Though material and mechanical properties of titanium make it attractive for load-bearing dental and orthopaedic implants, limited advancements have been made to increase success and survival after placement in the body. Novel surface modifications inducing combined micro- and nano-roughness on Ti and Ti-6Al-4V substrates contribute to increased wettability and can be tailored to affect cell response. Additive manufacturing can produce three dimensional constructs with natural, trabeculae-inspired porosity. Osteoblasts and mesenchymal stem cells are responsive to the porosity and detail of these constructs, and exhibit increased production of osteoblastic differentiation and maturation factors on porous constructs compared to solid substrates. Implants with trabecular porosity lead to vertical bone growth on rat calvaria, and osseointegrate in the rabbit femur. These results indicate that structural micro- and nano-modification at the surface, combined with macro-scale porosity, can enhance osteoblastic differentiation and maturation in vitro, and osseointegration in vivo. These implants are now being evaluated in clinical studies.
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/56287
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject biomaterials
dc.subject osseointegration, osteoblast differentiation
dc.subject titanium
dc.subject additive manufacturing
dc.title Multi-scale structural design of titanium implants for improved osseointegration
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Zhu, Cheng
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication d28f1a84-f07d-40ec-bed3-60bc4c140551
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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