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School of Public Policy

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https://hdl.handle.net/1853/70716

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Ivan Allen College of Liberal Arts

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Technology Policy and Assessment Center

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https://finding-aids.library.gatech.edu/agents/corporate_entities/1033

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Publication Search Results

Now showing 1 - 10 of 11

The Largest Unethical Medical Experiment in Human History

( 2020-02) Kostoff, Ronald N.

This monograph describes the largest unethical medical experiment in human history: the implementation and operation of non-ionizing non-visible EMF radiation (hereafter called wireless radiation) infrastructure for communications, surveillance, weaponry, and other applications. It is unethical because it violates the key ethical medical experiment requirement for “informed consent” by the overwhelming majority of the participants. The monograph provides background on unethical medical research/experimentation, and frames the implementation of wireless radiation within that context. The monograph then identifies a wide spectrum of adverse effects of wireless radiation as reported in the premier biomedical literature for over seven decades. Even though many of these reported adverse effects are extremely severe, the true extent of their severity has been grossly underestimated. Most of the reported laboratory experiments that produced these effects are not reflective of the real-life environment in which wireless radiation operates. Many experiments do not include pulsing and modulation of the carrier signal, and most do not account for synergistic effects of other toxic stimuli acting in concert with the wireless radiation. These two additions greatly exacerbate the severity of the adverse effects from wireless radiation, and their neglect in current (and past) experimentation results in substantial under-estimation of the breadth and severity of adverse effects to be expected in a real-life situation. This lack of credible safety testing, combined with depriving the public of the opportunity to provide informed consent, contextualizes the wireless radiation infrastructure operation as an unethical medical experiment.
COVID-19: Preventing Future Pandemics

(Georgia Institute of Technology, 2020) Kostoff, Ronald N. ; Briggs, Michael B. ; Porter, Alan L.

The COVID-19 pandemic has had global health and economic adverse impacts. The main measures being taken to control the spread of SARS-CoV-2 (the virus associated with COVID-19) are conceptually those that were taken to control the spread of SARS-CoV in the previous coronavirus-driven pandemic of 2002-2003: good hygiene, facemasks, and quarantine (lockdown). The difference is the larger scale of these measures for SARS-CoV-2. A weakened immune system appears to be the main determinant of serious/fatal reaction to viral infection (for COVID-19, SARS, and influenza alike). There are four major approaches being employed or considered presently to augment or strengthen the immune system, in order to reduce adverse effects of viral exposure. The three approaches that are mainly focused on augmenting the immune system are based on the concept that pandemics can be controlled/prevented while maintaining the immune-weakening lifestyles followed by much of the global population. The fourth approach is based on identifying and introducing measures aimed at strengthening the immune system intrinsically in order to minimize future pandemics. The four measures are: 1) restricting exposure to virus; 2) providing reactive/tactical treatments to reduce viral load; 3) developing vaccines to prevent, or at least attenuate, the infection; 4) strengthening the immune system intrinsically, by a) identifying those factors that contribute to weakening the immune system, then eliminating/reducing them as comprehensively, thoroughly, and rapidly as possible and b) replacing the eliminated factors with immune-strengthening factors. The present monograph focuses mainly on strengthening the immune system intrinsically. It identifies hundreds of factors that contribute to weakening the immune system, as well as measures that can strengthen the immune system. It also addresses the vaccine issue, since vaccine development has been emphasized in myriad forums. Potential mid-and long-term adverse vaccine effects that cannot be identified in short-term tests characteristic of efficacy testing are identified. To ensure safety, long-term testing under real-life conditions (exposures to multiple toxic stimuli) are required. There is an incompatibility between the accelerated vaccine development times being pursued by government and industry and the long times required for validation of vaccine safety. In summary, 1) there is not unanimity within the medical community for continuing post-lockdown the severe restrictions on activities of the vast majority of the total population that are mainly applicable to the most vulnerable very small minority of the total population; 2) repurposed (mainly) antiviral treatments can only be expected to have very limited results in controlling SARS-CoV-2 viral load of the most severely impacted, based on trials conducted so far; 3) it is difficult to see how safe COVID-19 vaccines can be developed and fully tested on time scales of one or two years, as proposed presently; 4) the only real protection against a future COVID-19 pandemic or any other viral pandemic is the one that was demonstrated to work in the SARS pandemic, the MERS pandemic, the COVID-19 pandemic, and in the annual influenza pandemics: a healthy immune system capable of neutralizing incoming viruses as Nature intended. We need an Operation Warp Speed (currently working to produce a vaccine in a record short time period in the USA) to identify and eliminate those factors that weaken the immune system as thoroughly, comprehensively, and rapidly as possible.
Prevention and Reversal of Chronic Disease: Lessons Learned

(Georgia Institute of Technology, 2019-11) Kostoff, Ronald N.

For a decade, our research group has been developing protocols to prevent and reverse chronic diseases. The present monograph outlines the lessons we have learned from both conducting the studies and identifying common patterns in the results. The main product of our studies is a five-step treatment protocol to reverse any chronic disease, based on the following systemic medical principle: at the present time, removal of cause is a necessary, but not necessarily sufficient, condition for restorative treatment to be effective. Implementation of the five-step treatment protocol is as follows: Step 1: Obtain a detailed medical and habit/exposure history from the patient. Step 2: Administer written and clinical performance and behavioral tests to assess the severity of symptoms and performance measures. Step 3: Administer laboratory tests (blood, urine, imaging, etc) Step 4: Eliminate ongoing contributing factors to the chronic disease Step 5: Implement treatments for the chronic disease This individually-tailored chronic disease treatment protocol can be implemented with the data available in the biomedical literature now. It is general and applicable to any chronic disease that has an associated substantial research literature (with the possible exceptions of individuals with strong genetic predispositions to the disease in question or who have suffered irreversible damage from the disease). To prevent any chronic disease, eliminate those contributing factors that serve as a basis for Step 4.
Adverse Effects of Wireless Radiation

(Georgia Institute of Technology, 2019-10) Kostoff, Ronald N.

This monograph identifies adverse effects of wireless radiation as reported in the premier biomedical literature. It shows that most of the laboratory experiments that have been performed are not designed to elicit the more severe adverse effects reflective of the real-life operating environment in which wireless radiation is embedded. The monograph includes a substantial bibliography of papers that present these adverse effects, and shows that what has been reported is the tip of the iceberg of the full spectrum of potential adverse effects from wireless radiation.
Strengthening exposure limits for toxic substance combinations

(Georgia Institute of Technology, 2019) Kostoff, Ronald N.

Toxic stimuli exposure limits are typically based on single stressor experiments, but are presently applicable to toxic stimuli in isolation or in combination with other toxic stimuli. In the latter case, typically less of each constituent of the combination is required to cause damage compared to the amount determined from single stressor experiments. This monograph presents a simplified approach to improving regulatory exposure limits for toxic stimuli. The approach will partially account for the enhanced adverse effects of toxic stimuli combinations. It 1) assumes that all potential toxic stimuli to which an individual might be exposed have the same mechanisms/modes of action on biological mechanisms, and are, thus, indistinguishable by the impacted organism; 2) converts the doses of exposures to toxic stimuli to NOAEL fractions; 3) adds all the NOAEL fractions from these exposures to toxic stimuli; and 4) divides all the present exposure limits by the total number of NOAELs obtained. It would reduce present single-stressor-based exposure limits by an order of magnitude or more across the board. The newly posited approach does not account for hormetic, antagonistic, or synergistic effects of toxic stimuli in combination. It does not adjust for 1) low-dose toxicants with adverse effects that have been under-reported, or 2) exposure limits (like the OSHA PELs) that are orders of magnitude above levels shown by published single stressor studies to have caused adverse effects.
Prevention and Reversal of Peripheral Neuropathy/Peripheral Arterial Disease

(Georgia Institute of Technology, 2019) Kostoff, Ronald N.

This monograph presents a five-step treatment protocol to prevent and reverse Peripheral Neuropathy (PN)/Peripheral Arterial Disease (PAD), based on the following systemic medical principle: at the present time, removal of cause is a necessary, but not necessarily sufficient, condition for restorative treatment to be effective. Implementation of the five-step PN/PAD treatment protocol is as follows: Step 1: Obtain a detailed medical and habit/exposure history from the patient. Step 2: Administer written and clinical performance and behavioral tests to assess the severity of the higher-level symptoms and degradation of executive functions Step 3: Administer laboratory tests (blood, urine, imaging, etc) Step 4: Eliminate ongoing PN/PAD contributing factors Step 5: Implement PN/PAD treatments This individually-tailored PN/PAD treatment protocol can be implemented with the data currently available in the biomedical literature. Additionally, while the methodology developed for this study was applied to comprehensive identification of diagnostics, contributing factors, and treatments for PN/PAD, it is general and applicable to any chronic disease/condition that, like PN/PAD, has an associated substantial research literature. Thus, the protocol and methodology developed to prevent or reverse PN/PAD can be used to prevent or reverse any chronic disease (with the possible exceptions of individuals with strong genetic predispositions to the disease in question or who have suffered irreversible damage from the disease).
Effects of Toxic Stimuli Combinations on Determination of Exposure Limits

(Georgia Institute of Technology, 2018) Kostoff, Ronald N.

This monograph addresses the effects of toxic stimuli combinations on determination of safe Exposure Limits. It shows these combinations 1) typically lower the threshold constituent exposure levels associated with damage compared to 2) tests of combination constituents run in isolation. The monograph concludes there is no reason to believe today that ANY of the Exposure Limits on potentially toxic stimuli that have been set by ANY of the regulatory agencies are fully protective against serious adverse health effects. While radiofrequency radiation (RFR) is used for illustrative purposes in a number of the examples presented, the conclusions are applicable to essentially all potential contributing factors to disease amenable to Exposure Limits. RFR combinations are the focal point in Appendix 2, where their potential role in contributing to the national/global opioid epidemic is also discussed.
Treatment Repurposing using Literature-Related Discovery

(Georgia Institute of Technology, 2018) Kostoff, Ronald N.

Treatment Repurposing is the application of an existing treatment to diseases or symptoms of interest other than the disease(s) or symptom(s) for which the treatment was developed (and used) initially. It includes, but goes well beyond, Drug Repurposing. The present monograph uses Literature-Related Discovery (LRD) to identify treatments that could be repurposed for diseases of interest. The LRD methodology for identifying candidate repurposable treatments is presented in detail, and illustrative examples are provided from a recent monograph on prevention and treatment of Alzheimer's Disease. The present monograph also contains an extensive Bibliography of the core Treatment Repurposing literature, as well as two novel taxonomies of this literature. One taxonomy uses text clustering to display the myriad categories (and their relationships) in this Treatment Repurposing literature, and the other taxonomy uses factor analysis to display the myriad categories/themes in the same literature.
OSHA Permissible Exposure Limits (PELs) are too Permissive

( 2018) Kostoff, Ronald N.

The present monograph examines the differences (for selected toxic substances) between 1) the Federal legally enforceable occupational Permissible Exposure Limits (PELs) set by OSHA and 2) low-level exposures reported in the biomedical literature associated with serious adverse effects. In these selected cases, the PELs are orders of magnitude higher than what the premier biomedical literature would suggest is protective. Our previous monograph on combinations of stressors (https://smartech.gatech.edu/handle/1853/59719) concluded that testing of single stressors (the main determinant of myriad types of Exposure Limits), rather than combinations of stressors, greatly under-estimates the toxicity of the stressors in real-world environments. When these 1) stressor combination conclusions are added to the 2) results from the present monograph, one can 3) seriously question whether present-day Exposure Limit regulations offer credible levels of occupational protection from any potentially toxic stressors.
Prevention and Reversal of Alzheimer's Disease

(Georgia Institute of Technology, 2017) Kostoff, Ronald N. ; Zhang, Yi ; Ma, Jing ; Porter, Alan L. ; Buchtel, H.A.

This monograph identifies the full spectrum of hundreds of actionable Alzheimer's Disease (AD) contributing factors, covering the broad categories of Lifestyle, Iatrogenic, Biotoxic, Environmental/Occupational, and Psychosocial/Socioeconomic. Eliminating or reducing these actionable contributing factors offers the promise of potentially preventing and reversing AD in selected cases, and also offers the promise of dramatically lowering AD healthcare costs by circumventing the need for 1) expensive high technology AD diagnostics and treatments and 2) expensive extended maintenance and care of individuals with AD. The monograph also describes the text mining/information technology advances that allowed the AD actionable contributing factors to be identified and extracted efficiently from the large numbers of biomedical journal articles retrieved.