Organizational Unit:

School of Public Policy

Permanent Link

https://hdl.handle.net/1853/70716

Parent Organization

Organizational Unit

Ivan Allen College of Liberal Arts

Includes Organization(s)

Organizational Unit

Technology Policy and Assessment Center

ArchiveSpace Name Record

https://finding-aids.library.gatech.edu/agents/corporate_entities/1033

Full item page

Publication Search Results

Now showing 1 - 10 of 16

Communicable diseases are not communicable

(Georgia Institute of Technology, 2020-10) Kostoff, Ronald N. ; Briggs, Michael B. ; Kanduc, Darja ; Porter, Alan L. ; Buchtel, Henry A.

Communicable disease is a misnomer. The disease is not communicable; the microbe mainly associated with the disease is communicable. Whether the recipient of the microbe develops the disease depends on the health of the recipient’s immune system. Our model of COVID-19 development starts with real-life exposures to multiple toxic stressors degrading the immune system. This is followed by the SARS-CoV-2 virus exploiting the degraded immune system to trigger a chain of events ultimately leading to COVID-19. To prevent or treat infectious disease, the health of the immune system must be maintained or improved. One major component of maintaining and improving immune system health is removal of those factors that contribute to immune system degradation. A previous monograph identified many factors that contribute to immune system degradation (Contributing Factors (CFs)). It was hypothesized that many of these CFs to immune system degradation were identical to those that past studies have shown were CFs to chronic diseases. To test this hypothesis, a proof-of-principle demonstration was performed to identify the commonality between CFs to immune system degradation and CFs to Parkinson’s Disease (PD). A very streamlined approach was used, and approximately 500 CFs were found in common between the two diseases. Since COVID-19 (and other infectious diseases) results from immune system degradation in our model, this means COVID-19 and PD are enabled by many of the same toxic exposures and toxic behaviors. Thus, many of the measures required to strategically treat and prevent infectious diseases are similar to those required to strategically treat and prevent chronic diseases. This is a major paradigm shift for orthodox Western medicine, but is required to achieve major advances in global population health.
Combining Tactical and Strategic Treatments for COVID-19

(Georgia Institute of Technology, 2020-03) Kostoff, Ronald N.

As of mid-March, 2020, many countries in the world are on partial lockdown, to control the spread of the pandemic (COVID-19) resulting from the SARS-CoV-2 coronavirus. The only effective ‘treatments’ at this time are good hygiene and quarantine. This document presents a novel combined tactical and strategic treatment approach for COVID-19 that incorporates both the tactical and strategic approaches we have developed for preventing and reversing myriad diseases, including treatment repurposing as well. Optimally, the tactical and strategic approach components would be implemented in parallel, to provide benefit from the synergies of the combined approach.
The Largest Unethical Medical Experiment in Human History

( 2020-02) Kostoff, Ronald N.

This monograph describes the largest unethical medical experiment in human history: the implementation and operation of non-ionizing non-visible EMF radiation (hereafter called wireless radiation) infrastructure for communications, surveillance, weaponry, and other applications. It is unethical because it violates the key ethical medical experiment requirement for “informed consent” by the overwhelming majority of the participants. The monograph provides background on unethical medical research/experimentation, and frames the implementation of wireless radiation within that context. The monograph then identifies a wide spectrum of adverse effects of wireless radiation as reported in the premier biomedical literature for over seven decades. Even though many of these reported adverse effects are extremely severe, the true extent of their severity has been grossly underestimated. Most of the reported laboratory experiments that produced these effects are not reflective of the real-life environment in which wireless radiation operates. Many experiments do not include pulsing and modulation of the carrier signal, and most do not account for synergistic effects of other toxic stimuli acting in concert with the wireless radiation. These two additions greatly exacerbate the severity of the adverse effects from wireless radiation, and their neglect in current (and past) experimentation results in substantial under-estimation of the breadth and severity of adverse effects to be expected in a real-life situation. This lack of credible safety testing, combined with depriving the public of the opportunity to provide informed consent, contextualizes the wireless radiation infrastructure operation as an unethical medical experiment.
COVID-19: Preventing Future Pandemics

(Georgia Institute of Technology, 2020) Kostoff, Ronald N. ; Briggs, Michael B. ; Porter, Alan L.

The COVID-19 pandemic has had global health and economic adverse impacts. The main measures being taken to control the spread of SARS-CoV-2 (the virus associated with COVID-19) are conceptually those that were taken to control the spread of SARS-CoV in the previous coronavirus-driven pandemic of 2002-2003: good hygiene, facemasks, and quarantine (lockdown). The difference is the larger scale of these measures for SARS-CoV-2. A weakened immune system appears to be the main determinant of serious/fatal reaction to viral infection (for COVID-19, SARS, and influenza alike). There are four major approaches being employed or considered presently to augment or strengthen the immune system, in order to reduce adverse effects of viral exposure. The three approaches that are mainly focused on augmenting the immune system are based on the concept that pandemics can be controlled/prevented while maintaining the immune-weakening lifestyles followed by much of the global population. The fourth approach is based on identifying and introducing measures aimed at strengthening the immune system intrinsically in order to minimize future pandemics. The four measures are: 1) restricting exposure to virus; 2) providing reactive/tactical treatments to reduce viral load; 3) developing vaccines to prevent, or at least attenuate, the infection; 4) strengthening the immune system intrinsically, by a) identifying those factors that contribute to weakening the immune system, then eliminating/reducing them as comprehensively, thoroughly, and rapidly as possible and b) replacing the eliminated factors with immune-strengthening factors. The present monograph focuses mainly on strengthening the immune system intrinsically. It identifies hundreds of factors that contribute to weakening the immune system, as well as measures that can strengthen the immune system. It also addresses the vaccine issue, since vaccine development has been emphasized in myriad forums. Potential mid-and long-term adverse vaccine effects that cannot be identified in short-term tests characteristic of efficacy testing are identified. To ensure safety, long-term testing under real-life conditions (exposures to multiple toxic stimuli) are required. There is an incompatibility between the accelerated vaccine development times being pursued by government and industry and the long times required for validation of vaccine safety. In summary, 1) there is not unanimity within the medical community for continuing post-lockdown the severe restrictions on activities of the vast majority of the total population that are mainly applicable to the most vulnerable very small minority of the total population; 2) repurposed (mainly) antiviral treatments can only be expected to have very limited results in controlling SARS-CoV-2 viral load of the most severely impacted, based on trials conducted so far; 3) it is difficult to see how safe COVID-19 vaccines can be developed and fully tested on time scales of one or two years, as proposed presently; 4) the only real protection against a future COVID-19 pandemic or any other viral pandemic is the one that was demonstrated to work in the SARS pandemic, the MERS pandemic, the COVID-19 pandemic, and in the annual influenza pandemics: a healthy immune system capable of neutralizing incoming viruses as Nature intended. We need an Operation Warp Speed (currently working to produce a vaccine in a record short time period in the USA) to identify and eliminate those factors that weaken the immune system as thoroughly, comprehensively, and rapidly as possible.
COVID-19 Vaccine Safety Considerations

(Georgia Institute of Technology, 2020) Kostoff, Ronald N. ; Kanduc, Darja ; Porter, Alan L. ; Shoenfeld, Yehuda ; Briggs, Michael B.

The SARS-CoV-2 pandemic has produced global health and economic adverse impacts. The main measures being taken to control the spread of SARS-CoV-2 and of the virus-associated diseases (COVID-19) are conceptually those that were taken to control the spread of SARS-CoV in the previous coronavirus-driven pandemic of 2002-2003: good hygiene, facemasks, and quarantine (lockdown). The difference is the larger scale of these measures for SARS-CoV-2. A degraded/dysfunctional immune system appears to be the main determinant of serious/fatal reaction to viral infection (for COVID-19, SARS, and influenza alike). There are four major approaches being employed or considered presently to augment or strengthen the immune system, in order to reduce adverse effects of viral exposure. The three approaches that are focused mainly on augmenting the immune system are based on the concept that pandemics can be controlled/prevented while maintaining the immune-degrading lifestyles followed by much of the global population. The fourth approach is based on identifying and introducing measures aimed at strengthening the immune system intrinsically in order to minimize future pandemics. Specifically, the four measures are: 1) restricting exposure to virus; 2) providing reactive/tactical treatments to reduce viral load; 3) developing vaccines to prevent, or at least attenuate, the infection; 4) strengthening the immune system intrinsically, by a) identifying those factors that contribute to degrading the immune system, then eliminating/reducing them as comprehensively, thoroughly, and rapidly as possible, and b) replacing the eliminated factors with immune-strengthening factors. A previous monograph [1] focused mainly on strengthening the immune system intrinsically, and secondarily on vaccine-related issues. It identified many hundreds of factors that contribute to weakening the immune system, as well as measures that can strengthen it. The present monograph focuses on vaccine safety. A future COVID-19 vaccine appears to be the treatment of choice at the national/international level globally. Vaccine development has been accelerated to achieve this goal in the relatively near-term, and questions have arisen whether vaccine safety has been/is being/will be compromised in pursuit of a shortened vaccine development time. In addition to identifying short-term adverse vaccine effects, the present monograph identifies potential mid-and long-term adverse vaccine effects that cannot be identified in short-term tests characteristic of vaccine efficacy testing. To ensure vaccine safety, long-term testing under real-life conditions (exposures to multiple toxic stimuli) is required. There is an incompatibility between the accelerated vaccine development times being pursued by government and industry and the long times required for validation of vaccine safety. In summary, it is difficult to see how safe COVID-19 vaccines can be developed and fully tested for safety on development time scales of one or two years, as proposed presently. The only real protection against a future COVID-19 pandemic or any other viral pandemic is the one that was demonstrated to work in the SARS, MERS, and COVID-19 pandemic, and in the annual influenza pandemics: a healthy immune system capable of neutralizing incoming viruses as nature intended.
Prevention and Reversal of Chronic Disease: Lessons Learned

(Georgia Institute of Technology, 2019-11) Kostoff, Ronald N.

For a decade, our research group has been developing protocols to prevent and reverse chronic diseases. The present monograph outlines the lessons we have learned from both conducting the studies and identifying common patterns in the results. The main product of our studies is a five-step treatment protocol to reverse any chronic disease, based on the following systemic medical principle: at the present time, removal of cause is a necessary, but not necessarily sufficient, condition for restorative treatment to be effective. Implementation of the five-step treatment protocol is as follows: Step 1: Obtain a detailed medical and habit/exposure history from the patient. Step 2: Administer written and clinical performance and behavioral tests to assess the severity of symptoms and performance measures. Step 3: Administer laboratory tests (blood, urine, imaging, etc) Step 4: Eliminate ongoing contributing factors to the chronic disease Step 5: Implement treatments for the chronic disease This individually-tailored chronic disease treatment protocol can be implemented with the data available in the biomedical literature now. It is general and applicable to any chronic disease that has an associated substantial research literature (with the possible exceptions of individuals with strong genetic predispositions to the disease in question or who have suffered irreversible damage from the disease). To prevent any chronic disease, eliminate those contributing factors that serve as a basis for Step 4.
Adverse Effects of Wireless Radiation

(Georgia Institute of Technology, 2019-10) Kostoff, Ronald N.

This monograph identifies adverse effects of wireless radiation as reported in the premier biomedical literature. It shows that most of the laboratory experiments that have been performed are not designed to elicit the more severe adverse effects reflective of the real-life operating environment in which wireless radiation is embedded. The monograph includes a substantial bibliography of papers that present these adverse effects, and shows that what has been reported is the tip of the iceberg of the full spectrum of potential adverse effects from wireless radiation.
Strengthening exposure limits for toxic substance combinations

(Georgia Institute of Technology, 2019) Kostoff, Ronald N.

Toxic stimuli exposure limits are typically based on single stressor experiments, but are presently applicable to toxic stimuli in isolation or in combination with other toxic stimuli. In the latter case, typically less of each constituent of the combination is required to cause damage compared to the amount determined from single stressor experiments. This monograph presents a simplified approach to improving regulatory exposure limits for toxic stimuli. The approach will partially account for the enhanced adverse effects of toxic stimuli combinations. It 1) assumes that all potential toxic stimuli to which an individual might be exposed have the same mechanisms/modes of action on biological mechanisms, and are, thus, indistinguishable by the impacted organism; 2) converts the doses of exposures to toxic stimuli to NOAEL fractions; 3) adds all the NOAEL fractions from these exposures to toxic stimuli; and 4) divides all the present exposure limits by the total number of NOAELs obtained. It would reduce present single-stressor-based exposure limits by an order of magnitude or more across the board. The newly posited approach does not account for hormetic, antagonistic, or synergistic effects of toxic stimuli in combination. It does not adjust for 1) low-dose toxicants with adverse effects that have been under-reported, or 2) exposure limits (like the OSHA PELs) that are orders of magnitude above levels shown by published single stressor studies to have caused adverse effects.
Prevention and Reversal of Peripheral Neuropathy/Peripheral Arterial Disease

(Georgia Institute of Technology, 2019) Kostoff, Ronald N.

This monograph presents a five-step treatment protocol to prevent and reverse Peripheral Neuropathy (PN)/Peripheral Arterial Disease (PAD), based on the following systemic medical principle: at the present time, removal of cause is a necessary, but not necessarily sufficient, condition for restorative treatment to be effective. Implementation of the five-step PN/PAD treatment protocol is as follows: Step 1: Obtain a detailed medical and habit/exposure history from the patient. Step 2: Administer written and clinical performance and behavioral tests to assess the severity of the higher-level symptoms and degradation of executive functions Step 3: Administer laboratory tests (blood, urine, imaging, etc) Step 4: Eliminate ongoing PN/PAD contributing factors Step 5: Implement PN/PAD treatments This individually-tailored PN/PAD treatment protocol can be implemented with the data currently available in the biomedical literature. Additionally, while the methodology developed for this study was applied to comprehensive identification of diagnostics, contributing factors, and treatments for PN/PAD, it is general and applicable to any chronic disease/condition that, like PN/PAD, has an associated substantial research literature. Thus, the protocol and methodology developed to prevent or reverse PN/PAD can be used to prevent or reverse any chronic disease (with the possible exceptions of individuals with strong genetic predispositions to the disease in question or who have suffered irreversible damage from the disease).
Prevention and reversal of Alzheimer's disease: treatment protocol

(Georgia Institute of Technology, 2018-01-23) Kostoff, Ronald N. ; Porter, Alan L. ; Buchtel, Henry A.

This monograph presents a five-step treatment protocol to prevent and reverse Alzheimer's Disease (AD), based on the following systemic medical principle: at the present time, removal of cause is a necessary, but not necessarily sufficient, condition for restorative treatment to be effective. The five treatment protocol steps are as follows: Step 1 - obtain a detailed medical and habit/exposure history from the patient; Step 2 - administer written and clinical performance and behavioral tests to assess the severity of the higher-level symptoms and degradation of executive functions; Step 3 - administer laboratory tests (blood, urine, imaging, etc.); Step 4 - eliminate ongoing AD contributing factors; Step 5 - implement AD treatments. This individually-tailored AD treatment protocol can be implemented with the data available in the biomedical literature presently. Additionally, while the methodology developed for this study was applied to AD, it is general and applicable to any chronic disease that, like AD, has an associated substantial research literature. Thus, the protocol and methodology we have developed to prevent or reverse AD can be used to prevent or reverse any chronic disease (with the possible exceptions of individuals with strong genetic predispositions to the disease in question or who have suffered irreversible damage from the disease).***NOTE***There are four files in this record. Presently, they are located in the left column of this Web page listed under the heading View/Open. MONOGRAPH_FINAL.pdf contains the monograph narrative; FIGURES_FINAL.xlsx contains the figures from the monograph in Excel spreadsheet format; SUPPLEMENTARY_FINAL.pdf contains supplementary bibliography and queries; and README.pdf is the ReadMe file. The two data files are referenced in the monograph as either "(see file FIGURES_FINAL.xlsx)" or "(see file SUPPLEMENTARY_FINAL.pdf)".