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ItemEmerging technology for the poor: how nanomedicine and public private partnerships are used to address diseases of poverty(Georgia Institute of Technology, 2014-06-19) Woodson, Thomas S.Decreasing the number of people that die from preventable illnesses and reducing poverty and inequality are major public goods that are being addressed from a variety of angles. One way that policy makers and scholars are trying to improve global health is by developing new health technologies that will decrease poverty and inequality. This dissertation investigates whether nanotechnologies for medical applications (nanomedicine) are used to address diseases of poverty (DoP) and the role that public partnerships (PPP) play in nanomedicine research. If scientists are developing nanotechnology based vaccines and medicines for DoP, then I can conclude that the technology is helping to decrease poverty and inequality. There are two parts to my analysis. The first part of my dissertation analyses the landscape of nanomedicine DoP research and then I test how USA medicine sales, disease burden and diseases of poverty correlate with number of nanomedicine publications and patents. I find that there is some nanomedicine research on diseases of poverty, especially for high profile DoP like malaria, tuberculosis and HIV/AIDS, but overall there is less R&D on DoPs than non-DoPs. However, I cannot determine if USA medicine sales and disease burden have any relationship to research output. In the second part of my dissertation I examine the role of formal public-private partnerships (PPPs) for developing DoP medicines. Many think the formal health PPPs can overcome the various market failures associated with developing medicines for DoP. I analyze PPP websites and interview PPP managers/scientists about their research portfolios, relationship with nanotechnology, and how PPPs are addressing inequality in health R&D. I find that managers/scientists at PPPs have a variety of opinions about nanotechnology, but the general consensus is that nanotechnology will not be used in the near-term for DoP medicines. PPP managers/scientists believe that the technology is too expensive for DoP medicines and it will take too long to approve nanomedicines. Instead of using nanotechnology most PPPs are in favor of using traditional technologies.
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ItemA cross country investigation of social enterprise innovation: a multilevel modelling approach(Georgia Institute of Technology, 2014-04-08) Monroe-White, Thema K.This dissertation presents a multilevel model of national-level factors and their impact on the organizational-level characteristics of social enterprises and their innovations. This study builds on the foundations of two theoretical frameworks: the national systems of innovation, which recognizes economic competitiveness to be a product of several interrelated institutions (e.g. financial, educational, cultural, historical) and where organizational-level innovation drives country level competitiveness; and the comparative social enterprise framework, which contends that national-level institutions (e.g., economic competitiveness, models of civil society) drive the size and shape of the social enterprise sector of a country. Data for this study were collected from multiple secondary global datasets representing 54 countries across seven world regions. Research questions and hypotheses are examined using ordinal and logistic hierarchical generalized linear modeling, two analytical techniques capable of explaining variation at one level (i.e., organizations) as a consequence of factors at another level of analysis (i.e., countries) for non-normally distributed dependent variables. Findings indicate that economic competitiveness, welfare spending, culture and quality of life significantly impact the odds of a business being a social enterprise. Fewer significant relationships were found social enterprise innovations. Conclusions and policy implications are discussed in light of data limitations and the current state of the field.
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ItemNuclear medicine: policy context for differences between Europe and the United States(Georgia Institute of Technology, 2013-11-19) Roldan Rueda, Diana MarcelaThe World Health Organization published in 2004 a bulletin addressing the gap between research, technology, and its implementation in the health systems of different countries (Haines, Kuruvilla, & Borchert, 2004). Among the barriers described for the implementation of new knowledge in the medical practice is the lack of connection between research results and policy makers. This happens in different subfields within the medical field. The focus of this project is to analyze the differences in implementation of radionuclide therapy technology between the EU and the US. The hypothesis is that this technology has been implemented in the EU earlier and more often than in the US, and that this variation can be connected to the differences in the policies relevant to nuclear medicine. Nuclear medicine is a unique field because of the way radioactive material is used to create diagnostic images and treat illnesses (mostly cancer). Although radiation is used every day in radiotherapy and radiology, the main difference between these two fields and nuclear medicine is the type of radiation used. Radiotherapy and radiology use closed sources of radiation, or particle accelerators that produce radiation, while nuclear medicine uses open sources of radiation that are injected into the patient’s body. This is an important difference because the accelerators used in radiotherapy and radiology can be turned on and off unlike the open sources of radiation used for nuclear medicine. If not handled properly, open sources of radiation may cause radiation contamination. Additionally, the radioactive material must be supplied on a daily basis. With nuclear medicine is possible to create diagnostic images of the body, and to record bodily functions all the way down to the molecular level. It is also possible to treat certain illnesses, such as some types of cancer, in a targeted manner. This is possible because the radioactive material is “connected” with a chemical compound (or drug) that carries the radioactive atoms to a desired location in the body; this is called targeted therapy. It is also possible to inject the radioactive material directly into the organ or region of interest. The targeted therapy and injected techniques are two processes that are part of radionuclide therapy technology. In order to check the status of the implementation of radionuclide therapy I used the practice guidelines published on the websites of the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine (SNM) in the US. Assuming that the practice guidelines are evidence of well-established and implemented techniques in the regions, these documents were evaluated according to their content and publication date. The content analysis was focused on the type of practices described: diagnostic, general, or therapy, as well as the type of radioactive material (or radioactive isotopes) used in such practices. The practice guidelines evaluation was done in Nvivo, a text analysis software. In addition to the analysis of practice guidelines, a bibliometric analysis of four databases (Pubmed, Medline, Biosis, and ISI Web of Science) was conducted in four databases. The keywords used for the search were (“radionuclide therapy” AND case AND report) OR (radioinmunotherapy AND case AND report). Case reports are publications that expose the day-to-day practice of physicians, and allow medical personnel to take a detail look into a specific case. The records from these sources were analyzed in Vantage Point, a bibliometric analysis software. From the policy landscape, three main types of policies were studied in relation to the practice of nuclear medicine: first, the education standards for the different professionals involved; second, the policies related to the approval of radiopharmaceuticals in the different drug administration entities; and finally, the policies concerning the production of radionuclide therapies in the two regions. The main finding of this project is that Europe and US have different policy approaches that affect, directly or indirectly, the nuclear medicine field. The main differences are in the standards of education for nuclear medicine specialist that is divided between radiologist and nuclear medicine specialists in the US; the production of radioactive material, which is commercially supplied by a very few reactors in the world, none of them in the US; and the drug administration institutions, which have very different approaches approving new drugs. Aditionally, Europe has implemented more radionuclide therapy technologies than US. From the practice guidelines analysis, it was evident that the US started publishing guidelines for nuclear medicine several years before Europe. The US published its first guideline in 1994, while the EU’s first guideline was published in 2000. However, as of July 2013, the European association had published more guidelines with 54 unique ones versus 49 from the US. EU also leads in the number of guidelines in regards to therapy, with 13 versus 2 from the US. Additionally, there is more variety in the radioisotopes used in therapy than the ones in diagnostics, and all the radioisotopes are mentioned in the European guidelines, while the US doesn’t have guidelines that mention Lu-177, Re-186, and Y-90 isotopes. From the bilbiometric analysis it was evident that Europe had published case reports for more time and more frequently than the US regarding radionuclide therapy. The first case report record from Europe was published in 1988, almost a decade before the first case report in the US. Additionally, the US has only 10 publications that match the keywords while the EU has 37. In conclusion, the EU has more practice guidelines on radionuclide therapies regarding more types of illnesses and more radioisotopes, and Europeans have published more case reports on these therapies, which indicates that the EU has implemented radionuclide therapy technology more fully than has the US. The differences in the policies and standards in education for Nuclear Medicine may influence this difference, because EU has a more standardized education and a more unified professional field than US. While the EU has a proposed syllabus for nuclear medicine practitioners, medical physicists, and radiopharmacists, in the US the education is neither standardized nor unified. Two different boards can certify physicians specializing in nuclear medicine: the American Board of Radiology and The American Board of Nuclear Medicine. The first one does a Nuclear Radiology certification for which the physicians are not required or allowed to conduct radionuclide therapies, while the American Board of Nuclear Medicine requires more nuclear medicine training and involves diagnostics and therapy. These differences are important in the implementation of radionuclide therapy techniques, because not all the nuclear medicine physicians in the US are trained on this aspect or allowed to practice it. For that reason a fraction of the professionals may not be interested or informed about these techniques, leaving the field of nuclear medicine in the US behind its EU counterpart. The policies that involve the production of radioisotopes and the market for this good deeply affects the status of the field in both regions. Since most of the radionuclide materials for therapies are produced in nuclear reactors, this is a very complex topic. Nuclear reactors are recognized for their capability to produce nuclear energy and not frequently associated with medicine. The precautionary approach that some regions apply to this topic may affect the availability of the radioisotopes in local markets. The EU has more nuclear reactors capable of the production of materials for radionuclide therapies, while the production of radioisotopes in the US is less and it focused on research. Therefore, the EU has a more stable and reliable supply of radioisotopes, which allows them to use the technology in everyday practice. Finally, the drug administration entities seem to differ in the clarity of their procedures for the approval of radiopharmaceuticals. The EU tools for approval are clear and easy to find, which may encourage European researchers to work on new radiopharmaceuticals and to carry their findings to the application level. The European Medicines Agency has a Radiopharmaceutical Drafting Group that supports the creation and approval of radiopharmaceuticals. In addition, one of the practice guidelines from the European Association of Nuclear Medicine (EANM) is about the approval of new drugs. This is not replicated in the US; although the Food and Drug Administration (FDA) has a special group that works with radiation therapies and devices, there are no references to a group that relates to radiopharmaceuticals, or the information is not as easy to find. It also looks like the Society of Nuclear Medicine (SNM) is focusing more on research and approval of Positron Emission Tomography (PET) radiopharmaceuticals than on therapy based ones. This is understandable since the radioactive material for PET images is produced in cyclotrons available at many clinics and hospitals around the world. In conclusion, nuclear medicine is a very diverse field that is capable of important contributions to medicine. However, the radioactive nature of the material needed for the development of new radionuclide therapies presents a barrier to the development of new drugs. The availability of the drug and the personnel trained in these matters are the most important factors for the successful use of this technology. Although the US and the EU have been collaborating more and more in the creation of standardized procedures for nuclear medicine, it is evident that the EU has more experience in the day to day application of the technology, and the technology is also more accessible in the EU by the physicians interested in it. A trained and informed group of professionals can raise awareness in the public and influence the policy making by monitoring agencies to create clearer paths for drug approvals, and pushing for laws that approve the research and production of alternatives for radioisotopes production such as Low Enriched Uranium reactors.
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ItemElectricity planning in West Africa: which way forward? An adaptive management perspective on energy policy(Georgia Institute of Technology, 2013-05-20) Soumonni, OgundiranAfrica’s quest for economic development will require the increased availability and use of its abundant energy resources. Nevertheless, most of its rural population remains without access to modern energy services and urban residents typically only enjoy an intermittent supply of electricity. The dominant approach to energy planning in West Africa is top-down and centralized, emphasizing electricity generation from large dams or fossil-fueled plants and subsequent grid extension to reach more customers. However, an alternative and complementary paradigm is that of decentralized or Distributed Generation (DG), which stresses small-scale, on-site generation of power and offers a bottom-up approach to energy development. The goal of this dissertation project is to assess the various options for regional electrification and integration through a holistic analysis of the set of existing technologies and policies for deploying them. The main organ of the Economic Community of West African States (ECOWAS) for regional electricity planning is the West African Power Pool (WAPP) and its primary policy document, the “Master Plan”, addresses regional power supply shortage through centralized planning. Both the WAPP policy documents and the majority of the country-level planning documents are considered to be based on a traditional, empiricist, policy analysis that appears to provide value-neutral solutions and generalizations. In contrast, the analysis provided in this project situates itself within the post-positivistic, deliberative and more contextual approach to policy analysis in order to compare the centralized approach to generation with a distributed approach, which is currently marginal in the region. It uses the Adaptive Management (AM) framework for this analysis, particularly because of the way it deals with ecological resilience in the face of widespread uncertainty. The main policy issue that this project seeks to address is the need for an integrated energy-environment planning process, which is currently lacking in West Africa, so as to achieve long term sustainability. Adaptive management offers policy makers a holistic lens with which to view energy policy, but there are very few examples of institutions that have attempted to implement it in practice anywhere in the world. These instances, however, represent a valuable historical reference point for future policy research and management efforts that seek to explore this approach. In alignment with that objective, this dissertation first provides an overview of the concept of adaptive management in general, and its application to energy problems in particular. Secondly, the research project undertakes a policy analysis of the ECOWAS strategy for electrification, based on a stakeholder analysis, a review of life cycle assessments of existing energy technologies, the expected outcomes of the electricity sector, and a set of traditional criteria for evaluating public policies. In order to further examine the question of electricity access, it carries out a quantitative analysis of the electricity demand and supply in the region. It uses a modeling approach that is based on the logic of AM to determine whether or not the energy requirements for broad based electrification can be met through distributed renewable power, which is currently a negligible component of the generation resource portfolio in West Africa. The dissertation proceeds to carry out a retrospective analysis of three cases in the U.S. where elements of AM have already been applied to energy planning in order to investigate some of the critical determinants for its successful implementation to date. This assessment then informs a prospective analysis of three West African cases that have ideal characteristics for experimentation with AM to determine to what extent similar concepts have been used, or may be employed in the future. The AM framework also calls for the consideration of local values, which should be open to revision in the face of real situations. To this end, the prospective analysis includes three additional place-sensitive criteria, so as to ensure that the framework remains viable in a different socio-political context. The AM analyses are then extended to include a discussion of learning and innovation in clean energy technologies, drawing from the Chinese, Danish and South African experiences. The results suggest that a strong and consistent political will that is in alignment with an explicit social policy is needed to initiate and implement broad-based electrification plans, but that stakeholder participation is critical to their success. In addition, the adoption of multiple instruments and the selection of a diverse range of energy resources were found to be more effective than an overreliance on a single dominant scheme so as to allow room for policy learning. Furthermore, the results confirm that a holistic approach to managing ecosystems associated with electric power production is a fruitful way to integrate ecological considerations with social and economic factors throughout the development of a project. This type of systemic methodology should also include the building of technological capability and the development of innovation capacity in order to address the unique socio-economic context and the rapidly-changing climatic conditions in West Africa. Finally, the articulation of a planning philosophy that engages the values and sensibilities of the people in a particular place, and that is rooted in them, was found to be a critical factor for increasing the level of public participation in management activities in order to achieve more equitable and democratic outcomes.
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ItemNanotechnology research in the US agri-food sectoral system of innovation: toward sustainable development(Georgia Institute of Technology, 2013-01-17) Cortes-Lobos, RodrigoNanotechnology, the scientific study of manipulating matter on an atomic scale (1 to 100 nanometers) that provides new properties in materials and devices had received considerable research attention and public funding support during the last decade in the US. This emerging technology promises to improve the competitiveness of most of the US industrial sectors. Malerba (2004) an innovation system researcher has developed the theoretical framework "Sectoral System of Innovation (SSI)" to study the process by which new technologies and knowledge are produced and transferred to industrial sectors, where actors interact based on an institutional framework to generate innovation processes. In this dissertation I studied the agriculture and food processing sector, which is a key sector of the US economy that has provided with enough food for the US population, but in an unsustainable way that has harmed the environment, natural resources and human health. The US agrifood sector is facing new challenges of increasing food demand, which need to be addressed in a more sustainable way that takes consideration on economic, environment, and social aspects. The main questions that this dissertation research focuses on studying how much attention the public nanotechnology agrifood research agenda has paid to sustainability issues during the last decade in the US and what role has played the system's actors in influencing this research agenda. The analysis of the policy process in which system's actors try to influence the research agenda is framed in the Advocacy Coalition Framework (Sabatier 1993) that complemented the Sectoral System of Innovation approach in studying the formation of advocacy groups to achieve their coalition's policy goals. Three data sources were utilized to achieve my research goals, the CNS-ASU nanotechnology publications dataset 2000-2010(Porter A, Youtie J et al. 2007; De Bellis 2009)which was used to conduct a bibliometric analysis of the agrifood nanotechnology research publications in the US, semi-structured interviews with key actors and their interaction in advocacy coalition groups, and a literature review of several official documents and public hearing with respect to the US nanotechnology system to evaluate the influence of advocacy groups in the policy process. Utilizing Vantage point data mining and Nvivo qualitative analysis software I conducted the data analysis of my research. The results show increasing research attention toward environmental research and food safety issues that can indirectly impact positively on sustainability development, as well as increasing research attention in studying environmental, health and safety issues (EHS) that can reduce potential risks. The analysis of actors' interaction to influence the policy process, two advocacy coalitions was identified. On one side, a coalition that advocate for more research funding oriented to applied research to achieve the potential that this coalition members believe this technology has to revolutionize the way food is produced giving more competitiveness to the US agrifood sector, this coalition is composed by researchers, federal agency managers and industry representatives. On the other side, a rival coalition that raise concerns respect to potential risks associated to this technology that required to be addressed by the public research agenda. This coalition mainly composed by environmental non-governmental organizations (NGOs) and other social actors claim for a regulatory framework that guarantee a nanotechnology development environmental friendly that benefit the society. The influence of these two coalitions have succeed in allocating more federal funding resources to research nanotechnology in the agrifood sector, with particular emphasis in EHS research that show the right path to a sustainable development that guarantee enough resources for the future generations.
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ItemPublic financing of risky early-stage technology(Georgia Institute of Technology, 2012-08-24) Galope, ReynoldThis dissertation examines the role of public investments in inducing small firms to develop risky, early-stage technologies. It contributes to expanding our understanding of the consequences of research, innovation, and entrepreneurship policies and programs by investigating in more depth the effect of the Small Business Innovation Research (SBIR) program on the innovation effort, ability to attract external capital, and other metrics of post-entry performance of small business start-ups using a new sample and estimation approach. Unlike prior R&D subsidy studies that concentrated almost exclusively on European countries, this dissertation focused on small business start-ups in the United States using a new scientific survey of new firms. It integrated the Kauffman Firm Survey (KFS) from the Ewing Marion Kauffman Foundation with the SBIR recipient dataset from the U.S. Small Business Administration (SBA) and used advances in statistical matching to achieve better comparability between the treated and control groups of small business start-ups. The integrated KFS-SBA dataset, which contains both recipient and non-recipient small firms, and statistical matching allowed us to empirically construct the counterfactual outcomes of SBIR recipients. This dissertation balanced the pre-treatment characteristics of SBIR recipients and non-recipients through propensity score matching (PSM). It constructed the comparison sample by identifying non-recipients with nearly identical propensity scores as those of SBIR recipients. Consistent with the propensity score theorem, observations with the same distribution of propensity scores have the same distribution of observable characteristics. PSM made the comparison and treatment samples homogenous except in SBIR program exposure, making the fundamental assumption of ignorability of treatment assignment more plausible. Using the realized outcomes of observationally similar non-recipient start-ups as the counterfactual outcomes of SBIR recipients, we found empirical evidence of the input additionality effect of the SBIR program. Had they not applied for and granted SBIR R&D subsidies, recipient start-ups would have spent only $185,000 in R&D, but with SBIR their R&D effort was significantly increased to $663,000, on average. The treatment effects analyses also found a significant positive effect of SBIR on innovation propensity and employment. However, it appears that public co-financing of commercial R&D has crowded-out privately financed R&D of small business start-ups in the United States. A dollar of SBIR subsidy decreased firm-financed R&D by about $0.16. Contrary to prior SBIR studies, we did not find any significant "halo effect" or "certification effect" of receiving an SBIR award on attracting external capital. However, we discovered a different certification effect of the SBIR program: SBIR grantees are more likely to attract external patents. This finding also confirms that innovation requires a portfolio of internal and external knowledge assets as theorized by David Teece and his colleagues. This dissertation's empirical results may be relevant to the Small Business Administration, SBIR participating agencies, the U.S. Congress, other federal, state and local policymakers, small high-tech start-ups, and scholars in the field of science, technology, and innovation policy.
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ItemCommunity-based innovation dynamics in the water supply and sanitation (wss)sector(Georgia Institute of Technology, 2012-07-03) Catalan, PabloFor most of the one billion people living in extreme poverty worldwide, access to an adequate water supply and basic sanitation (WSS) is limited, resulting in substantial health, economic and social burdens. Although the international community has actively explored solutions to this crisis, primarily focusing on bottom-up approaches in which the beneficiaries participate in the design and implementation of their own WSS solutions, significant problems remain. Innovation presents an important source of feasible solutions in this sector for those in need, but insufficient study exists to allow scholars to determine the dynamics that trigger WSS innovation. In light of the recent emphasis on a bottom-up approach to water issues and the dearth of analysis with regard to the role WSS innovation plays in seeking solutions, the present dissertation sets out to explore innovation dynamics in relation to the establishment of rural Water Supply and Sanitation Community-Based (WSS-CB). The answer comes through an application of a qualitative methodology that focuses on the implementation of two publicly-run and sustainability-oriented programs - the Blue Flag Ecological Program (BFEP) and the Sanitarian Quality Seal Program (SQSP) - in three rural communities in Costa Rica. A theoretical model based on the conceptual frameworks of Systems of Innovation (SI), Community Based/Community Management (CB/CM), and the Institutional Analysis Development (IAD) theory is proposed, including two set of hypotheses addressing the contribution of two independent variables, the participation of the community and the capacity of the community, to local sustainability and local learning. The results show that the dynamics relating to leadership and a sense of ownership do, in fact, affect both dependent variables and further identify participation and interaction at decision-making and social venues as innovation drivers.
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ItemPublic participation in science and technology policy: consensus conferences and social inclusion(Georgia Institute of Technology, 2012-05-18) Bal, RavtoshThis study looks at the National Citizens' Technology Forum (NCTF), a modified version of the consensus conference, which took place in March, 2008 in six cities across the U.S. to understand how inclusive these methods of public participation are in practice. The research focused on two of these sites. Inclusion of participants was defined in terms of presence, voice and being heard. Transcripts of the audio-visual recordings of the proceedings were the main data of analysis. By focusing on the talk within these deliberative forums, the study looked at how the rules of engagement and status (ascribed and achieved) differences between participants can affect inclusion. The analysis did not reveal any substantial effects of ascribed characteristics on deliberation. Facilitation and the presence of expertise among the participants were found to influence inclusion and equality among participants. These findings suggest that organizers and facilitators of deliberative exercises have to be reflexive of their role as well as aware of the group dynamics. The results also address the larger questions within science and technology policy like the role of expertise and the public in decision making, the institutional design of participatory exercises, and their relation to the political culture and the policy process.
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ItemDynamics of innovation of biofuel ethanol. three decades of experience in the U.S. and in Brazil(Georgia Institute of Technology, 2010-11-15) Berger, Elena M.This dissertation draws on the burgeoning field of innovation of low carbon technologies. Using the functions of innovation systems, this study explores the process of innovation of biofuel ethanol in the U.S. and in Brazil. It uses "process theory" to build a narrative of historical events that represent the innovation trajectory of ethanol biofuel in the U.S. and in Brazil over a period of thirty years. The data is drawn from newspaper articles from the New York Times, Washington Post, and O Estado de Sao Paulo published between 1975 and 2008. Results of this research confirm findings published previously that innovation performs better when the main actors in the innovation process act under clear and well defined policy targets, and when the innovation environment contributes to building positive expectations about the technology. The empirical findings build upon the literature and validate early claims that the alignment of goals between technology producers and users is an inducer of innovation. Moreover, the analysis presented shows that by developing new capabilities, technology users in the downstream market broaden the innovation environment and facilitate the adoption of the emerging technology by new users and markets. For example, the automobile sector has been participating actively in the ethanol technological innovation system in Brazil, facilitating the innovation flow between upstream and the downstream market. This has not been the case in the U.S., where the automobile sector has not found incentives to participate in the ethanol technological innovation systems.
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ItemOnline deliberation among regional civil society groups - the case of the Caribbean(Georgia Institute of Technology, 2010-07-08) Thakur, DhanarajDeliberative democracy has been promoted as a way improving legitimacy and political equality in policy debates. This dissertation seeks to understand how deliberation takes place within the intersection of two unique spaces: dialogue among members of regional civil society groups and communication in online fora. The motivation for this research is based on the notion that existing forms of decision-making have contributed to political inequality, a major issue in areas such as the Caribbean. Accordingly I examine the online discussions of three different civil society groups in the Caribbean. I looked at how certain variables in these fora were related to three of the main dimensions of deliberation, the use of reasoned arguments, reciprocity and reflection. With regard to reasoned arguments I examined how diversity among members, the participation of the moderator and the topic and scope of the conversation were pertinent to a discussion in a regional and multi-national setting. For reciprocity I looked at how variables related to time and the posting structure of a conversation were relevant in an online forum. Finally I looked at the strategies that were employed by participants as part of the communication process in an online forum and how these were related to processes of reflection. To address these questions I used a combination of content analysis and conversation analysis of email conversations and interviews with participants. One set of contributions from this dissertation is methodological through the development of a codebook and the novel application of conversation analysis to online deliberation. Also, the results are significant and can contribute to our understanding of deliberation in a context for which there has been little previous research. For example, I showed that national and occupational diversity can contribute to an increase in the proportion of reasoned arguments used in a conversation as does the presence of the moderator. However, these factors along with the scope and topic of a thread vary in their degree of influence on the use of reasoned arguments by the civil society group in question. I also showed that there are specific communication strategies that participants employ such as preference organization or speaker selection that are related to different forms of reflection evident in a conversation. Finally I observed that the posting structure of a conversation specifically the distribution of emails that participants send becomes less equal as reciprocity increases. This does not augur well for a deliberative ideal that envisions both reciprocity and equal participation. Furthermore, when considering deliberation as a whole, the results indicate that its different parts are not always correlated with each other. None of the lists has more than one significant correlation between the three dimensions of deliberation. In fact, reciprocity and the use of reasoned arguments were never significantly correlated in any of the lists. Together these results point to another main finding of this dissertation which is deliberation as a whole is difficult to observe in practice. Nevertheless I suggest that separately the results for each dimension can be useful from both a design perspective and for policy-makers in general. For example, encouraging the sharing of information and a more active moderator, having the opportunity to discuss regional issues could all help to promote a greater use of reasoned arguments overall. Experimenting with different ways in which group members can get to know each other might help to reduce the disparity between participation and reciprocity. Also encouraging participants to reply inline where possible, creating easier access to the message archives and having a system for collating threads and discussions online could all promote better reflection in the lists. Finally the list might benefit from having members go through an exercise of determining whether or not and in what way decision-making should be part of their discussions. With regard to policy-makers I note that several members reported benefits for policy-makers who themselves were members of the lists. This could stem from listening and learning from the discussions of other members or actually contributing to discussions. The groups also showed the potential to collate many different policy positions around a specific problem, thus assisting policy makers in understanding issues at a regional level.