Hello my name the chancel I am a regents
professor of biomedical engineering.

I have been at Georgia Tech since one
nine hundred ninety when I joined

as assistant professor in the wood
to school of mechanical engineering.

I started having a split appointment

with the coater department
of biomedical engineering.

Soon after it started in one
thousand nine hundred ninety eight.

And I moved one hundred percent to the
CO Department in two thousand and five.

When I assume the position of associate
chair for international programs.

I want to tell you about my research.

Here you're looking at
a website of my lap.

Let me see if I can get any pointer.

So this is a more.

More or less reason photo of the lap
taking in the I.B.P. Atran the stairs.

Worse.

My lap located it in lap wing three B..

Some of the people have left but we have.

New people joining So
the lab is roughly fifteen people where.

That manager research scientist.

Post docs and.

Ph D. students and
a couple of NASA students as well.

We call it solar and
molecule Obama can explain.

And let me show you next.

The research we do particular project.

If you click on the Richard side then.

Was summary of the researchers.

So in a single sentence.

I'll say that.

Our research is the power
physics of the A he isn't and

signaling molecules in the mill system and
vascular systems.

Let me give you examples
of the particular disease

processes or the physiological processes
where our research is focused on.

Here is there in famine Turly
reaction when you have infection or

injury the wipe ourselves
normally flow in the circulation

would then buy into the in the third
zero cells which is the inner

lining of your blood vessel at
the sites of infection or injury and

here showing the wife cells interacting
with the in the through cells and

that process involves molecules.

Called the immigrants and
solar panels depicted here and

the process recruits Y.
plus cell to the site of infection and

then they migrate out to sites were
the back truth and wire fence.

That invaded the body.

Now this cartoon.

He picked the another system
which is the lymphocytes.

Recognition of pathogens.

Now this is a very important process and

that's how our dept of
immune system started.

Of course if you screwed up with

this then you wouldn't be
able to recognize pathogens.

That invades you.

If you had over sensitive immune reaction
that mistakenly recognize yourself.

As intrude Hurst.

And you have auto immune diseases and
in fact our lap.

Some of the research project has to
do with auto immune diseases such as

multiple sclerosis.

OK so.

Three car tongs here depicts
molecules of interest.

Involved in the process is
that I describe to you.

In the process of peace our
recognition of pathogens.

A key molecule receptor and

of course there are us a number
of other assess three molecules.

Some of the molecules are in a good and
that's the picture here

in the in family through action I mention
about selected Mr Pickett here and

Pisa Latin for example at its contra
molecule ally gets called P.S.G. zero one.

Here in the and

in a rat with a extracellular
matrix protein core fiber Nekton.

F. and for short.

Now I mentioned earlier that our
research also involves problems of the.

Vascular system.

In particular here most days this and
from both of us.

Of course the most racist is
the process of stop bleeding.

Montane in your blood pressure
when you have injury of course you

do beat if you cannot your body cannot
stop bleeding you bleed to death.

The other extreme of that
process is called a Form bosis.

Now we know.

In most cases or

the process of stop bleeding involve a
frak amount of blood called the platelets.

As one poses is when played its.

Form actually gets.

In your blood vessel which would
block a plug that was so would lead.

Adding to the heart attack
in some cases of strokes.

The molecule of interest.

In our lab are one.

What about a factor and ends I call
Adam Pierce thirteen cleaved one about

a factor in the molecules on the play
that called it one called the G.P.S..

One B five NY.

Compaq's OK now.

This cartoon also depicts.

The experiment hope.

Technique that we use one of the anyway
it's called a comic force microscope so

here is using atomic force
microscope to upright forces

to stretch the complex between a you
know going Alpha Phi Beta one and

then anybody against it or
the like and five when I can honestly.

Let me see if I can bring you.

Images.

Yes.

I so here we should have some

kind of tone saw images of the experiment
no technique that we use in our lap.

I mention a permit force microscope.

Or A F M.

It's how you can think of
it as a fish fishing pole.

Which is this can deliver you
have a baby here and you go fish.

Now when you catch a fish
then your fishing pole Ben.

This laser hits on the back
of the fishing pole and

bends off into a photo that I detect
the bending amount of your fishing pole.

So you can sense the amount.

Force or how heavy your fish is.

And there are none of other things
to do the fishing pole up and

down and controls the movement and
measured a force.

This is a knot or.

Technology that use in our lab called
a bomb and bring forth a pole.

It's similar to F.

in that you need a fishing pole type
of thing in order to measure force and

in this case the fishing pole is rounded
It's a human reprobate cells aapc.

Now it's more like a drum you
push in the center of the drum

the drum bends in wards or buckles inward.

But you can also put it at
the center outwards and

then it would bend the other way around.

You can think of this as a rounded
out Drum where you had a B.

here attached to the apex and
the other side is like munging

the drum onto a cylinder here
you have suction pressure so

that the membrane of the rep last cell.

Has some tension when your prior force

pulling on this way then of
course the Iraq stretched.

So you can use this to sense
the interaction force between molecules on

the beat and molecules on the other so
that it is aspirated into a not a pipette.

This technique has on the Manage of.

Measuring force with
live cells wires here.

Typically we use purifying molecules.

This.

Rep our cell has a much
softer remembering.

So a smaller spring constant
of your string gauge

compared to the candy they were used to.

Here.

This is a lower lower tech version
of the bomb them bring force pro.

We typically use it to measure
Malique interaction but

the readout is not as precise we
know we had our force we simply say

there is a he's in a lower here so
it's a digital.

Binary beat out.

So here shows you another approach we

take in Allah progress research problems
and this is a computational one.

Instead of experimental and
it's called a molecular dynamic simulation

empty simulation you supercomputer
calculate the trajectory and

interaction of as many as a million

atoms including water molecules
surrounding and the protein.

And we study how externally apply force or

Hirst the structure or confirmation of
a protein which can change function.

The last figure here shows
what we call a forest and

biosensor it's used to monitor.

Activity of proteins inside a living
cell using force and imaging technique.

OK So I think that's quite
a bit of research and.

We always welcome new students Ph D.
student post-ops.

We have backgrounds in.

Engineering mechanical engineering
chemical engineering bomb

medical engineering or
science life science.

Chemistry Physics all welcome thank you.