[00:00:14]
>> It was a little early in the things it was an act of. Right not knowing all the terrorists around this time but there's also a tendency recuperation for the current quarter and so there are virtually nothing there. We also look at our activity during herbals call cannot sleep so our percent sure exactly this is our rebuttal so that a different way would you take the frequency content of our call is higher.

[00:00:54]
Frequency radar right here is what we used to detect her purse down here in yellow is a war of words and. I never look closely at the frequency printed very many Americans are. You going to stick around for a reference he is called here on here on solutions.

[00:01:19]
And gives his study to many different brain regions in the paper here because we know previous work better during Tribbles is a poor word correlated with that replay or reactivation better black or higher gamma terror. So we also looked at this given act. And this is showing that they did actually walk and this is shocking to me and I think.

[00:01:45]
I did a very very very right but there's less here. Now if we look at fact different players should be given Howard over her stripper goals and you can see that there's less power. Fighting Marshall is also one of the more interested in giving his because her answer fire season here are slipping back to his apparent that so.

[00:02:12]
That is more legit fired place and that means more rounds of all of them fired together and for times that's important for things like Spike transmission. So we've also got various fighting Irish my game up with Ultra is over the effects are a consequence. So we're fighting back yonder answerable to start with the abundance of herds used in the fires of they.

[00:02:38]
Started even before defenses her accident and team are. Now really wonderful how about coming up I'll. Still be circles big and your muscle issues are we seeing are generated by the circus with the game and the campus that are part of a circus or in your simplified version are all right so the combination of criminal self turns have to work together to use these kinds of oscillations 1st time doing so is more of a piano oscillation we seem close going on is that spread yourself firing.

[00:03:21]
They soon are start to compete in terms and then make those cells fire and his arm computer itself the same aspect back onto the ground result and shock the criminals also this is a negative feedback. And you can see this is out of Colorado for us it would see spiky actually but because of that he turns this is from a Marxist I really think they can see the criminals are firing on to keep the Internet rounds fired and all the criminals electing the stocks are.

[00:03:53]
Not even trying to are hiring together various incorrect time because their couch so they can be easily hacked like away when they said they gave him one or that virus is electrically couples the next month or. So this produces this kind of. Spirit inside a worrier. Parasol fiery nothing else all very very So this kind of activity is keeping intra.

[00:04:22]
In Vision but weeks of education needs to 1st published next week and the circuitry is built the right way and cycles. So we think this is how am I right since as well as having it 1st present during circus soon to wonder if something could be wrong on a leash and how these neurons answer each other for all the staff at the same cells in the.

[00:04:51]
Naturalist understand why these circles and be able. To do where you know you can assess that journey behaviors this is again our work we're in for animals well 30 years and we can use what we call about him on the stand so we record spiking activity multiples of times and it can be used on a site with a virus themselves identified that this fugitive Bramble cells are found and if we can ask this cell might be a missile firing and basically never came across correlations misfired cells so if this is our base the cell fire.

[00:05:33]
When this cell fires itself would be more likely to also spike and then one of their eyes like what it was like after the last time for right. So we give us that with our cross crowd RAM So this is showing you know a crash program or I want to be honest.

[00:05:54]
And this is a carousel that we have is hugely honest. And that's because this piece is above the baseline area and then it can measure back actions strength take back area that is a baseline area. We can also do that for him to trade action so in this cell terms of office hours you should expect to start the hour after.

[00:06:25]
This issue in example of active cross relations by trends and you see a depression here and one of severance suggests this is sour actually. And you mentioned that. So good luck to those connections in the fire lines and what you find is that there's a significant decrease in this in addition.

[00:06:50]
In trying to talk to criminals that's showbiz which here we look at maybe sections are a scarcer this is a long while to get like you see there's a clear do break here that's the Union mission and the rebels are up and they're fighting city most recently back to.

[00:07:08]
Where there's a time. When they're trying to fight back connection string is that significantly lower it's a cure everything stated several times this is on the side that there's less of this. Or not I'm just showing you this direction and not even here it's that when the circles happen and we see a similar deficit during both favorite band circles and.

[00:07:35]
Then everyone gets all the different reactions there are some other changes as well and Iraq occasionally but mostly this is a really good most striking one of all the different kinds of parents. Who are fighting deficits is that the fact is. This will be as important as they can help us understand where to shop for them and thus are coming from but also people noted on the systematic deficit of course active last as a part of especially early on or sell off and this is as overstating the slice as a this is hope.

[00:08:12]
It has to be a family with even the snap to take a set on how to actually eat carrots and I like to be one. All right so so do their differences in shutter their goals and they're not directional verticals and also the criminal interactions history and vision.

[00:08:35]
And what I will what happens it will stimulate some activity that's lacking and I'm going to stay wherever stimulating activity and part is because we are constantly. Present inquisitors to nature but as an artist or. So. I can say this is our high level overview of how I think about it.

[00:08:59]
But never. Thinking about stealing actually or sorry about Couldn't we have a different tact and just look this current size is exactly right to be crudely effective electric and solid And you. Can make people use other forms of course because there's a little bit of prior work issues you could basically turn up or turn down the activity at time or turned out to them in a spoiler if we could stimulate this treatment see just get back to the wholesome fresh life.

[00:09:36]
You know usually the 1st English music to accept oxygen taxes very moment it is anybody's it is just mice. But it makes no sense sensitive to light and that you put in place a fire in the region of interest and turn my fire off ignorance fire basically have a will with no 2nd act so we use a very similar approach right here that was initially just for us.

[00:10:05]
And that was to embarrass the crease else I mentioned that prices are very good part of reason we understand that there are actually. Case is weak people are just an interesting way to them and if you get down to eat after genetically stimulate those cells. And look at it like you know what's actually 1st let me just tell you we look 1st at where our Jerry heard so this is something this overall stimulation approach and this is the single phrase you can see before simulation after simulation there is a change it might be hard to see but I require that there is a.

[00:10:44]
Clear increase in 4 years activity for meetings where you heard stimulation so this is turning left on an average every 25. And this is that for your skin which is rarely also did our brain stimulation do so those neurons are light sensitive but instead of turning the lights laser like on with a $25.00 interval it's a great advantage for the whole overstimulated same amount but it is not for 40 years oscillation if you look closely related a little bit a little bit overweight Twinings are actually even viruses hers.

[00:11:28]
But it's not severe. And many are such good ghosting in Asia where the aerials have been infected with a controlled virus that is not like sensitive so you still turn away just a laser. ALSO SEE THAT is an increase in firing. Probably about like also the jury always are all right and $2.00 to $3.00 months after seeing increases aren't both reporters and writers.

[00:11:58]
So this isn't a dish or the counter I gave I was right here trying to order as I have an important role conditions for a good mission where I heard the same amounts of money it does not work. So there. It's a game where beta levels and this is a much bigger 14142 and these are different missions I just mentioned you said no stimulation were heard praying for the loss of gators.

[00:12:27]
I'm looking to see if there is a virus 50 percent reduction in Paralympic levels following this for years and this was done for and so on our next but are retired and microphone constant. But other frequencies radio and aprons not have that and also I understand this is another matter cell site and do not hers.

[00:12:57]
So it will have ballast surprising Tyson I'm just wondering how could that have so little you very much and what have you got out. You know how to change them like a levels come out so you liberals are functional and like they are actually and clearance and today to just focus on here is a particular card so I'll record we are.

[00:13:19]
There to kill or exist he also. Didn't really have many functions in the brain but what there is disorder and try to collectors break literally around take Can't wait for her chance broke down here. So we wonder if it is for your stimulation. And this is a shilling for the state and for my career I think.

[00:13:49]
I do these different missions of stimulation for your country and I think it's pretty clear that there's a difference here. And if you quantify back to France the fire more accurately or better lifestyle mind Erik's work. And these last 2 are associated with in growth that's where they rightly get it might be so we are.

[00:14:12]
So-called label for my failure so. I go where I could go and locate our little excerpt of Iraq that is out there that following 4 years there are Standage of my career or else like here. Still these were very interesting findings but we wonder if he was possible that this is really just a game not a plan that's up your side effects of our genetics like I said you have to support all this rapist English people that are in an expensive credit card but it does actually insert channels and.

[00:14:56]
It's probably letting healthy pledge neurons etc I did it 50 minutes to consider text site we want to see how this different way to see. Soon. One of the ways that we came up with was something called. Life Forever So basically he lived for decades the conflict for life liberty and drive that frequency universal were.

[00:15:26]
So good that our minds we were exposed to the hour of flights during our $48.00 hours or other there should be about 20 hertz a person right. For an hour and what to expect the lights turned off and on for of course. The 1st confirm that he was right returned to the.

[00:15:49]
Celestial here to give an increase to figures were going to increase or decrease our gives me not just a matter of oxygen and stimulation right there. I mean receiving all fired rates go up and down and go like this. Now the visual cortex is not background it also has disease.

[00:16:11]
But in this mask. I know there's an elevated levels in the usual way so you can ask the same question you just. Give them out as a good answer. And this is just to show you what it actually like her looks like. To a letter out and this is actually 21st not for her it's because 4 years is just fast for her to work your typical video frightening.

[00:16:41]
But you can see more of her flight. All right and this is very good to there might be a little more time after an hour of that letter and you can see it says this is dark and also supposed dark lights flickering corners flicker a flicker. And he didn't seem OK we're getting a few percent reduction and where you know obviously we've heard some of.

[00:17:09]
It was a look at several other dishes sit this one varies with people talking I'm getting tired. This is back 20 hertz in the city so you have a specific way with 40 acres but I get. Over 30 times in his economic time it's when you get this is character.

[00:17:30]
Gary is aren't necessary for a. Reason but I guess my 1st reaction might very similar changes all the others are increasing the number. And move on to number of different types as well and all the summer breeze so for your dislike for her she's clacks even older games but we're doing our game percent it's just.

[00:17:59]
Have to go through the same would be to gauge the wild type mice and other mouse models. And also reduced funds for it to have a very different mouse model prospects for the talent or. Well you're losing me I really are. Not for the average Americans I'm here and I'm not very.

[00:18:24]
So when wonderful Our job is 4 years late for possibly the last record we are this is actually a mass especially as I might wish for you here and. You know. So we basically have turns firing at 40 birds we have heard we are transforming our very hard life we are action but what happens if.

[00:18:49]
We are going to cheat molecules and bosses like me to the 2nd I say that's all right signalling molecules between cells really are well known for their rule and signal but this sort of raise other rules for the human taxes cell survival and. So they looked at side of higher levels all the 40 years later I missed it she got a little bit tired so this is said higher levels of one hour are for your slicker time reference letter here 20 hertz better way.

[00:19:22]
And I think you can see that for years flicker there is overall a lot more rare that higher levels and each one of the problems here is different so it's really across many different parts of the record. And that one of these roads are different. So overall see a lot more our higher settles for years but the only thing that's going on interesting 23rd seems to be the lowest grade of the summer and the White House is for.

[00:20:03]
This one does not work by. Side or moves differently to different conditions or a tirade that. Does analyses but people are different people so it's like all their claims to be. So we think that we're driving here not. That is we doing to you said kind of last record here and there are some areas showing that the same kinds are being out.

[00:20:36]
And least 5 rounds so out and suggested Americans are acting faster than United workers this is still over progress and we're still around but he is a really interesting M.T.M. think it's unprecedented and people but it's not commonly how. You go by everybody has to be it's of the brain and neurons let's do something different there's different categories or there are these really are interactions.

[00:21:09]
All right so I'll show you that their deficits the that is their activity director variables and they're trying to get our words uses it might be you know other points of policy as well as creating music like record we have in the house models actually I should mention that this is very interesting where something was so good for New Zealand and how many animals not just not models.

[00:21:39]
That you made were and how could we possibly translate this. Now learned how much is here is that 1st we would like to just stimulate in all sectors we'd like to stimulate the bridge it's like paper here I think with you this is particularly challenging to stimulate as it is so you can see if you're wearing There's a wire around.

[00:22:05]
Typical stimulation that is you have to stimulate everything above as well as I mean if you're single before you get losses or go a tree that there are you know you distinguish methods or I heard about that or it seemed like they could possibly hear your 1st person your favorite rabbit or you heard or you heard this kind of fast progress.

[00:22:34]
So we'll have a circling around it. Different forms of sensory stimulus this is word that I have often in my life. Had a certain friend running for Congress and like Flipper like the surgeon saying look at the effects of my flipper alone the campus could not produce large.

[00:22:58]
Changes for America we were like it's her and I like her it's me. I have a sound simple let's see if it works. OK I'll try to cream over the exact kind of like this because of above the law the reality is fat and a texture people who would be a music theory would call it texture because the sounds are so close together they sort of become one.

[00:23:33]
And syllable this is showing they're like Timothy during Bakrie. Stimulation this is lights and sound together and they sound alone just like Kansas very right so far. So this is I'll go raster classic trapeze styles a spike. And this is the overall firing rate suspects for time there are lines based on that list in the US the show which is so you can see the fiery because I think our sound going on and on and this is one example right this is different.

[00:24:08]
Let me see the clearer this is a partial truth axis of fire right here and right here right leg the primary cause I would have to call that. Your collar and actually pouring out. Your legs actually pretty similar to the darkness oscillations like tires and it's not that I start single phase of that oscillation me right now.

[00:24:34]
I also see very different effects of this. Why are our lives very different manner and we don't fully understand all of these differences in areas. Like you mentioned this season the result recently because we. Are perfectly. So we're learning that this is for you various products already for 4 years are radio like Twitter right for inspection you know.

[00:25:01]
There's a ton It's just silly to do not particular spike trees this is why example from where you heard of them here so you can see that this one they're on fire very very leaves over time to this. And getting back something that we're figuring out where there is that in terms of the animals and their state or their plasticity and changes going on over time and that's in the context.

[00:25:35]
Where those are sent some examples of quantifiers using circular statistics of basically a firing on it where are this where is that like our sounds are unlike our. And you can see the firing rate is higher on this part but it's not. Just a single firing visibly fires here anything human factor response here and I believe that my friends.

[00:26:04]
And I would if you measure back to strength for different missions or for 41st graders or interesting lation why are we find that there's a significantly higher tax rate for 4 years than the other. Although it is still I said I'm. Not really specific areas higher herds are.

[00:26:29]
Now out there gives one reason I'm interested in her disease the prefrontal cortex is a number and you can see degrees a little tense here very. To reach here is traditional business but there are areas that are not so doing great also that you target words and in fact history an example that did it 1st.

[00:26:52]
So what interests are trying like the great uses for it's making activity in multiple region for miles and others. Are a different it's not just for a person also reduce their frequency so and there's a sharing here a set of 20 herds in here it's going to be really clear if you go and there are still really fiery herds who they're not actually firing every every time turn on the light or sound firing their word likely they're fired phase but they hear.

[00:27:26]
These gives me only a fraction of the sensory pulses this is showing you that are higher here we're in here it's actually they're firing on a small fraction of the time that sensory system. Overall this could get interesting being waged decently Marshallese fighting Brigid started with each other so before you're sitting next to us to where because of that I think I think that we go back other frequencies our interest rate other so it's something I generally.

[00:28:05]
Missing wouldn't know doesn't back right well and the short answer is yes and this is our Deb Feyerick Tiger and Mark Rylance silent and and he looked back very similar X. where X. ray actually are very big around here because I'm just. And this is really in the back of the heart for years.

[00:28:27]
And you see some artifacts Now let me give you this is our after an hour a day for 7 days later due to release fireworks with the visuals licker. It's well over a get a very similar like really a transformation we also get our national life. Our production empires I think I'm getting us all the time for things.

[00:28:58]
Now that if we really translate this to human facts really get this stimulation get this on myself get into work. But we also need to be able to get out of this kind of stimulation not just. Do this together now immigrated their spouse that's for measuring be very.

[00:29:25]
Energy as well as she was on the way and that was my friend. To know that we're also magnets are fascinated me and sister as if I'm nice and I think that's interesting you know it's all scientifically but also because we're having similar mechanism of action and how nice.

[00:29:48]
So I mentioned to you before I was going back to our current model of the mechanism by which the interesting elation is affecting I quickly here my theory here is proof that neurons producing infrared signaling parents just for recess and. So that's interesting and their basic biology level but you can also look at the same time in humans is through the spinal fluid so it has potentially translational facts slower than traditional.

[00:30:21]
Alright so actually there are gases which are with the balls given the observable Emmy's prevalent in our interactions in the mouse model. And then we're driving here that reduces the likelihood of our team of the. He's a good motivator as was. Just mentioning passed on for a time and try to remember to recruit new music.

[00:30:46]
Like really our brain and then finally we can use visual and auditory flicker to drive him and I basically papers you can use it's seconds to text. And this is now leading us to see a new studies either we're doing in collaboration with other human researchers on these effects and some of those stories are very happy to help the subjects here and protect our collaboration with an investigator's I am very happy since.

[00:31:21]
Those are usually isn't small studies that we can figure out what the potential effects are sleeping design triggers there's a really big leap between mice and so there's technically alive things that go right back now. But reasons why they're seeing progress that was a nice enough work into one of those steps there.

[00:31:45]
But where it was also really interesting here is that for scientists really had not a link between I merely activity and the frequencies not to be entering the new cells but required to have Maisie's it's a decision your. Thoughts to leave where I asked for it activity in the brain and yet they indicated it was a list of diseases and this is a partial list this varying amounts of evidence for eternity so I might really or oscillations of it.

[00:32:18]
There's a lot of evidence and there's very little. But Harvey is it could potentially there could be a role for regard to the work I mean function. And that really needs to really hear their understanding of how the activity. And you can use system either good or bad.

[00:32:41]
How can we harness now however a stimulus was on to some other city where there's ample your what can we do with our information that knowledge as a way to potentially free. All right back is everything I started by saying I'd love to take my eyes Irish immigrants me for our causes difference between our son as well as our collaborators are I mean.

[00:33:11]
I would really very very. I of. Course wonder if my finding and point out that I have a conflict of interest I'm sure you know here is years of working martial arts for a person all for. A little slow little slow. But I guess work a. Little A.

[00:33:48]
Little bit warmer waters where you get a good result. But it might work better with you. Yeah so yes on the rest of my Twitter feed with her and how stupid I can see it unless they're programmed nicely for the night with their super. Bowl we don't know they're planting their houses frequently they're probably not hungry.

[00:34:17]
But that said. We aren't there and the. Terrorists are bring a whole host of issues are our. Could very surface nicely right in our environment where it's the largest most of all the time in fact where there's. I would guess no but I don't think that's what it is in the city in Psycho So yeah this is again saying OK so we is likely playing her will not leave his land.

[00:34:53]
Things like an abortion or church prayer and there's various studies that Excel. Disrupted sleep. Is correlated with things like animal or deposition or animals are also question but it's not there you know it's correlation not causation. But that said. There's no question that some are stimulation acting sleep or some of those processes as well because we are more.

[00:35:26]
License there might be mice are you know all of us are are light sensitive and this will be your legs for her cooties and come back in cycle privilege one of our only doing it our a flicker or less probably doesn't work in our day present days he is that kind of thing that is it is something.

[00:35:57]
So and I think a I said I'm here will give you a week and stopped there's not activity right or sleeping we have nothing to be anxious I'm in a context. And we're things like that although you can see the circles are very. Yes And people think back and so when riddles and this reactive exactly was 1st discovered I think some of the headlines this was decades ago.

[00:36:29]
And somebody said I think what are they going to present myself like you could see my house my stream of grass 3 you know because I was. That 1st patient. The rebels how many of their very slow wave sleep we're going to as we begin to train for this unless it seems happening very much so maybe not but.

[00:36:52]
Here in our. Ranch where the. Sort of brother general through. Your father or your. Mom. Well you. Know your son Yeah that's very much and so we're working with the president I mean my version of that would be pleasant. And I did that I'm glad of it but you have also recently this is your teammate is not that but if you don't know me who one is as a matter it is not your example and the interesting thing about working with a musician is she I was using fury like I think about and I was anxious and things turned off and I just thinking are.

[00:37:47]
Sort of on history of how these different signals are a bit more it sounds very big and Ira We don't know what the effects aria. Of you know for years what was that well you do for years. You know there are reports in the literature about interesting players using using Plessy to the seizures but good luck with that.

[00:38:16]
And why there's one very telling of a will there. Actually And I'm not sure of the word so here hundreds. Of. Billions of years ago. Yes. There you have it one that I really. Thought it would be. So with a little bruise or. A. Little bit so. Yeah I'm wondering what I was like yes I did find you have a lot of darkness I Yeah like how we go for a.

[00:39:05]
Moment when I 1st read it I guess I was yeah. Yeah yeah so you. Yes really little little bit I and my bigger question. Basically cleavages me to get a wife. And their couple their friends. My face or taste cancer cases or are. We going to talk more about it I haven't pursued it that I actually I think that I have my critical ear heard is.

[00:39:42]
Right now the Seattle Sounders I would say there's a debate about what's the. What's really underlying our anger. And what has been the thing for a very long time there was still absolutely. But there is now growing evidence that my grizzly are. And that's based on for a generic sense so there's never a government survive.

[00:40:12]
But I think personally and I think we are. Are really just not the kind of small but also in terms of player. So I focus myself very much. He apparently you know that's a good question so I mean somebody is a person you know also people use it for my education and then for you so caring there is for the 1st kind of stimulus that was in my time as part of meditation or focusing kind of activities you haven't explored all the time I suspect is a great question thing I'm.

[00:41:08]
Trying. Very. Hard. Here. My. Theory if you like a lot of. Interest. Here. Hold. It. Here. And you sit. Right. Here. On. Yeah we'll have the city would also be censoring our mind is a small state so that grounds that some here will see your tolerance but we are also measuring I should.

[00:42:29]
Biomarkers that could potentially help us understand what to do with workers and they're also sent. Other studies going on. Now are. I'm not quite as familiar with where they are exactly so it will be certainly was already have results that. We can. Meet center in our study but I think the reality is years before.

[00:42:59]
We came in anything. You know we are we are those of us we're really again we're really compare it like the 1st results I am giving the headers there's a lot it says you have to get to this 1st so far to save your hearts but I think that's a good thing but is it going to be a no stimulation or an art exhibit that you need to be stimulating.

[00:43:27]
Reading out we try to include different realities. Hopefully one that is there is a useful one. But there's a lot there's a lot of. Little. Old. People. Yeah that's a great question so the patients again included in our study are sitting or trial or early Alzheimer's is respond and Roger says that includes looking at him like our levels are reached to you as well as a mild memory may have to exclude other possible reasons so he'll also has a group of them over a 100 feel pretty confident about their medication but they are big those patients are going for a large crowd.

[00:44:25]
Your average person going to like very good records in our lives is going to probably last. All right thank you very much.